dc.creator | Muñoz Galván, Sandra | es |
dc.creator | García Rubio, María Luisa | es |
dc.creator | Ortega Moreno, Pedro | es |
dc.creator | Ruiz Pérez, José Francisco | es |
dc.creator | Jimeno González, Sonia | es |
dc.creator | Pardo, Benjamín | es |
dc.creator | Gómez González, Belén | es |
dc.creator | Aguilera López, Andrés | es |
dc.date.accessioned | 2017-06-06T11:17:00Z | |
dc.date.available | 2017-06-06T11:17:00Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Muñoz Galván, S., García Rubio, M.L., Ortega Moreno, P., Ruiz Pérez, J.F., Jimeno González, S., Pardo, B.,...,Aguilera López, A. (2017). A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination. PLoS Genetics, 13 (5), 1-18. | |
dc.identifier.issn | 1553-7390 | es |
dc.identifier.uri | http://hdl.handle.net/11441/61042 | |
dc.description.abstract | Replication forks stall at different DNA obstacles such as those originated by transcription. Fork stalling can lead to DNA double-strand breaks (DSBs) that will be preferentially repaired by homologous recombination when the sister chromatid is available. The Rrm3 helicase is a replisome component that promotes replication upon fork stalling, accumulates at highly transcribed regions and prevents not only transcription-induced replication fork stalling but also transcription-associated hyper-recombination. This led us to explore the possible role of Rrm3 in the repair of DSBs when originating at the passage of the replication fork. Using a mini-HO system that induces mainly single-stranded DNA breaks, we show that rrm3Δ cells are defective in DSB repair. The defect is clearly seen in sister chromatid recombination, the major repair pathway of replication-born DSBs. Our results indicate that Rrm3 recruitment to replication-born DSBs is crucial for viability, uncovering a new role for Rrm3 in the repair of broken replication forks. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Public Library of Science | es |
dc.relation.ispartof | PLoS Genetics, 13 (5), 1-18. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.publisherversion | 10.1371/journal.pgen.1006781 | es |
dc.identifier.doi | http://dx.doi.org/ 10.1371/journal.pgen.1006781 | es |
idus.format.extent | 19 p. | es |
dc.journaltitle | PLoS Genetics | es |
dc.publication.volumen | 13 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 18 | es |