dc.creator | Manterola, L. | es |
dc.creator | Hernando Rodríguez, M. | es |
dc.creator | Ruiz, A. | es |
dc.creator | Jiménez Muñoz, Sebastián | es |
dc.date.accessioned | 2017-03-15T14:05:28Z | |
dc.date.available | 2017-03-15T14:05:28Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Manterola, L., Hernando Rodríguez, M., Ruiz, A. y Jiménez Muñoz, S. (2013). 1–42 b -Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death. Translational Psychiatry, 3 (1), 1-12. | |
dc.identifier.issn | 2158-3188 | es |
dc.identifier.uri | http://hdl.handle.net/11441/55893 | |
dc.description.abstract | 1–42
b
-Amyloid peptide requires PDK1/nPKC/Rac 1
pathway to induce neuronal death
L Manterola
1,12
, M Hernando-Rodr
ı
́
guez
2,12
, A Ruiz
3,4
, A Apraiz
5
, O Arrizabalaga
5
, L Vello
́
n
6
, E Alberdi
3,4
, F Cavaliere
3,4
, HM Lacerda
7
,
S Jimenez
8,9
, LA Parada
10
, C Matute
3,4
and JL Zugaza
4,5,11
1–42
b
-Amyloid (A
b
1–42
) peptide is a key molecule involved in the development of Alzheimer’s disease. Some of its effects are
manifested at the neuronal morphological level. These morphological changes involve loss of neurites due to cytoskeleton
alterations. However, the mechanism of A
b
1–42
peptide activation of the neurodegenerative program is still poorly understood.
Here, A
b
1–42
peptide-induced transduction of cellular death signals through the phosphatidylinositol 3-kinase (PI3K)/
phosphoinositol-dependent kinase (PDK)/novel protein kinase C (nPKC)/Rac 1 axis is described. Furthermore, pharmacological
inhibition of PDK1 and nPKC activities blocks Rac 1 activation and neuronal cell death. Our results provide insights into an
unsuspected connection between PDK1, nPKCs and Rac 1 in the same signal-transduction pathway and points out nPKCs and
Rac 1 as potential therapeutic targets to block the toxic effects of A
b
1–42
peptide in neurons. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Nature Publishing Group | es |
dc.relation.ispartof | Translational Psychiatry, 3 (1), 1-12. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | 1–42 b -Amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.publisherversion | http://dx.doi.org/10.1038/tp.2012.147 | es |
dc.identifier.doi | 10.1038/tp.2012.147 | es |
idus.format.extent | 13 p. | es |
dc.journaltitle | Translational Psychiatry | es |
dc.publication.volumen | 3 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 12 | es |