Artículo
Oxidative Stress Correlates with Headache Symptoms in Fibromyalgia: Coenzyme Q10 Effect on Clinical Improvement
Autor/es | Cordero Morales, Mario David
Cano García, Francisco Javier Alcocer-Gómez, Elísabet Miguel Rodríguez, Manuel de Sánchez Alcázar, José Antonio |
Departamento | Universidad de Sevilla. Departamento de Personalidad, Evaluación y Tratamiento Psicológicos Universidad de Sevilla. Departamento de Psicología Experimental Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica |
Fecha de publicación | 2012 |
Fecha de depósito | 2016-12-22 |
Publicado en |
|
Resumen | Background: Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology and a wide spectrum of symptoms such as allodynia, debilitating fatigue, joint stiffness and migraine. Recent studies have shown some evidences ... Background: Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology and a wide spectrum of symptoms such as allodynia, debilitating fatigue, joint stiffness and migraine. Recent studies have shown some evidences demonstrating that oxidative stress is associated to clinical symptoms in FM of fibromyalgia. We examined oxidative stress and bioenergetic status in blood mononuclear cells (BMCs) and its association to headache symptoms in FM patients. The effects of oral coenzyme Q10 (CoQ10) supplementation on biochemical markers and clinical improvement were also evaluated. Methods: We studied 20 FM patients and 15 healthy controls. Clinical parameters were evaluated using the Fibromyalgia Impact Questionnaire (FIQ), visual analogues scales (VAS), and the Headache Impact Test (HIT-6). Oxidative stress was determined by measuring CoQ10, catalase and lipid peroxidation (LPO) levels in BMCs. Bioenergetic status was assessed by measuring ATP levels in BMCs. Results: We found decreased CoQ10, catalase and ATP levels in BMCs from FM patients as compared to normal control (P<0.05 and P<0.001, respectively) We also found increased level of LPO in BMCs from FM patients as compared to normal control (P<0.001). Significant negative correlations between CoQ10 or catalase levels in BMCs and headache parameters were observed (r = −0.59, P<0.05; r = −0.68, P<0.05, respectively). Furthermore, LPO levels showed a significant positive correlation with HIT-6 (r = 0.33, P<0.05). Oral CoQ10 supplementation restored biochemical parameters and induced a significant improvement in clinical and headache symptoms (P<0.001). Discussion: The results of this study suggest a role for mitochondrial dysfunction and oxidative stress in the headache symptoms associated with FM. CoQ10 supplementation should be examined in a larger placebo controlled trial as a possible treatment in FM. |
Identificador del proyecto | 2010/00000453
FIS PI10/00543 FIS EC08/00076 SAS 111242 CTS-5725 |
Cita | Cordero Morales, M.D., Cano García, F.J., Alcocer-Gómez, E., Miguel Rodríguez, M. y Sánchez Alcázar, J.A. (2012). Oxidative Stress Correlates with Headache Symptoms in Fibromyalgia: Coenzyme Q10 Effect on Clinical Improvement. PLoS One, 7 (4), e-35677 |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Oxidative Stress Correlates.PDF | 212.3Kb | [PDF] | Ver/ | |