dc.creator | Martínez de Pablos, Rocío | es |
dc.creator | Herrera Carmona, Antonio José | es |
dc.creator | Espinosa Oliva, Ana María | es |
dc.creator | Sarmiento Soto, Manuel | es |
dc.creator | Muñoz Pinto, Mario Faustino | es |
dc.creator | Machado Quintana, Alberto | es |
dc.creator | Venero Recio, José Luis | es |
dc.date.accessioned | 2016-05-25T11:08:32Z | |
dc.date.available | 2016-05-25T11:08:32Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Martínez de Pablos, R., Herrera Carmona, A.J., Espinosa Oliva, A.M., Sarmiento Soto, M., Muñoz, M.F., Machado de la Quintana, A. y Venero Recio, J.L. (2014). Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation. Journal of Neuroinflammation, 11, 1-18. | |
dc.identifier.issn | 1742-2094 | es |
dc.identifier.uri | http://hdl.handle.net/11441/41594 | |
dc.description.abstract | Background: Parkinson’s disease is an irreversible neurodegenerative disease linked to progressive movement
disorders and is accompanied by an inflammatory reaction that is believed to contribute to its pathogenesis. Since
sensitivity to inflammation is not the same in all brain structures, the aim of this work was to test whether physiological
conditions as stress could enhance susceptibility to inflammation in the substantia nigra, where death of dopaminergic
neurons takes place in Parkinson’s disease.
Methods: To achieve our aim, we induced an inflammatory process in nonstressed and stressed rats (subject to a
chronic variate stress) by a single intranigral injection of lipopolysaccharide, a potent proinflammogen. The effect of
this treatment was evaluated on inflammatory markers as well as on neuronal and glial populations.
Results: Data showed a synergistic effect between inflammation and stress, thus resulting in higher microglial activation
and expression of proinflammatory markers. More important, the higher inflammatory response seen in stressed animals
was associated with a higher rate of death of dopaminergic neurons in the substantia nigra, the most characteristic
feature seen in Parkinson’s disease. This effect was dependent on glucocorticoids.
Conclusions: Our data demonstrate that stress sensitises midbrain microglia to further inflammatory stimulus. This
suggests that stress may be an important risk factor in the degenerative processes and symptoms of Parkinson’s disease | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | BioMed Central | es |
dc.relation.ispartof | Journal of Neuroinflammation, 11, 1-18. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Glucocorticoids | es |
dc.subject | Lipopolysaccharide | es |
dc.subject | Microglia | es |
dc.subject | Parkinson’s disease | es |
dc.subject | Stress | es |
dc.subject | Substantia nigra | es |
dc.title | Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.publisherversion | 10.1186/1742-2094-11-34 | es |
dc.identifier.doi | http://dx.doi.org/10.1186/1742-2094-11-34 | es |
idus.format.extent | 18 p. | es |
dc.journaltitle | Journal of Neuroinflammation | es |
dc.publication.volumen | 11 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 18 | es |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/41594 | |