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dc.creatorHerrera González, María Doloreses
dc.creatorBueno, Rosarioes
dc.creatorÁlvarez de Sotomayor Paz, Maríaes
dc.creatorPérez Guerrero, María Concepciónes
dc.creatorVázquez Cueto, Carmen Maríaes
dc.creatorMarhuenda Requena, Elisaes
dc.date.accessioned2016-05-24T12:29:08Z
dc.date.available2016-05-24T12:29:08Z
dc.date.issued2002
dc.identifier.citationHerrera González, M.D., Bueno, R., Álvarez de Sotomayor Paz, M., Pérez Guerrero, M.C., Vázquez, C.M. y Marhuenda Requena, E. (2002). Endothelium-dependent vasorelaxation induced by L-carnitine in isolated aorta from normotensive and hypertensive rats. Journal of Pharmacy and Pharmacology, 54 (10), 1423-1427.
dc.identifier.issn2328-2150es
dc.identifier.urihttp://hdl.handle.net/11441/41534
dc.description.abstractThe aim of this work was to investigate the mechanism of the vasodilatory effect induced by L- carnitine. Relaxation produced by L-carnitine was studied in rat aortic rings with and without functional endothelium, pre-contracted with phenylephrine by adding cumulative doses of L- carnitine (10-7 to 10-3 M). The relaxation evoked by L-carnitine reached higher values in aortic rings from spontaneously hypertensive rats than those obtained in arteries from normotensive rats; no relaxation was produced in de-endothelialized arteries. However, in the presence of NG-nitro-L- arginine (3¬10-5 M, a nitric oxide synthase inhibitor), Ro 68070 (10-4 M, a thromboxane synthetase inhibitor–thromboxane A2/prostaglandin H2 receptor antagonist) or ICI 192605 (10- M, a thromboxane A2 receptor antagonist) the relaxant response to L-carnitine was signiicantly inhibited. These results show that L-carnitine induced endothelium-dependent relaxation in the rat aorta and the mechanism of this relaxation appeared to be mostly mediated by endothelial production of nitric oxide but also could involve prevention of the action of cyclooxygenase endothelial products acting on the thromboxane A2/prostaglandin H2 receptor.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherJPPes
dc.relation.ispartofJournal of Pharmacy and Pharmacology, 54 (10), 1423-1427.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleEndothelium-dependent vasorelaxation induced by L-carnitine in isolated aorta from normotensive and hypertensive ratses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Farmacologíaes
dc.relation.publisherversionhttp://dx.doi.org/10.1211/002235702760345536
dc.identifier.doi10.1211/002235702760345536
idus.format.extent5 p.es
dc.journaltitleJournal of Pharmacy and Pharmacologyes
dc.publication.volumen54es
dc.publication.issue10es
dc.publication.initialPage1423es
dc.publication.endPage1427es
dc.identifier.idushttps://idus.us.es/xmlui/handle/11441/41534

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Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional