Artículo
The GATC-binding protein SeqA is required for bile resistance and virulence in Salmonella enterica serovar Typhimurium
Autor/es | Ramos Morales, Francisco
Prieto Márquez, Ana Isabel Jakomin, Marcello Segura, Ignacio Pucciarelli, María Graciela García del Portillo, Francisco Casadesús Pursals, Josep |
Departamento | Universidad de Sevilla. Departamento de Genética |
Fecha de publicación | 2007 |
Fecha de depósito | 2016-03-01 |
Publicado en |
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Resumen | Disruption of the seqA gene of Salmonella enterica serovar Typhimurium causes defects similar to those described in E. coli: filament formation, aberrant nucleoid segregation, induction of the SOS response, envelope ... Disruption of the seqA gene of Salmonella enterica serovar Typhimurium causes defects similar to those described in E. coli: filament formation, aberrant nucleoid segregation, induction of the SOS response, envelope instability, and increased sensitivity to membrane-damaging agents. Differences between SeqA- mutants of E. coli and S. enterica, however, are found. SeqA- mutants of S. enterica form normal colonies and do not exhibit alterations in phage plaquing morphology. Lack of SeqA causes attenuation of S. enterica virulence by the oral route but not by the intraperitoneal route, suggesting a virulence defect in the intestinal stage of infection. However, SeqA- mutants are fully proficient in the invasion of epithelial cells. We hypothesize that attenuation of SeqA- mutants by the oral route may be caused by bile sensitivity, which in turn may be a consequence of envelope instability |
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The GATC-binding protein.pdf | 142.7Kb | [PDF] | Ver/ | |