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Artículo
SrfJ, a salmonella type III secretion system effector regulated by PhoP, RcsB, and IolR.
dc.creator | Ramos Morales, Francisco | |
dc.creator | Cordero Alba, Mar | |
dc.creator | Bernal Bayard, Joaquín | |
dc.date.accessioned | 2016-02-26T10:28:11Z | |
dc.date.available | 2016-02-26T10:28:11Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0021-9193 | es |
dc.identifier.uri | http://hdl.handle.net/11441/36622 | |
dc.description.abstract | Virulence-related type III secretion systems are present in many Gram-negative bacterial pathogens. These complex devices translocate proteins, called effectors, from the bacterium into the eukaryotic host cell. Here, we identify the product of srfJ, a Salmonella enterica serovar Typhimurium gene regulated by SsrB, as a new substrate of the type III secretion system encoded by Salmonella pathogenicity island 2. The N-terminal 20-amino-acid segment of SrfJ was recognized as a functional secretion and translocation signal specific for this system. Transcription of srfJ was positively regulated by the PhoP/PhoQ system in an SsrBdependent manner and was negatively regulated by the Rcs system in an SsrB-independent manner. A screen for regulators of an srfJ-lacZ transcriptional fusion using the T-POP transposon identified IolR, the regulator of genes involved in myo-inositol utilization, as an srfJ repressor. Our results suggest that SrfJ is synthesized both inside the host, in response to intracellular conditions, and outside the host, in myo-inositol-rich environments. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | American Society for Microbiology | es |
dc.relation.ispartof | Journal of Bacteriology, 194 (16), 4226-4236 | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | SrfJ, a salmonella type III secretion system effector regulated by PhoP, RcsB, and IolR. | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.publisherversion | http://jb.asm.org/content/194/16/4226.full.pdf | es |
dc.relation.publisherversion | http://dx.doi.org/10.1128/JB.00173-12 | |
dc.identifier.doi | 10.1128/JB.00173-12 | |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/36622 |
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SrfJ, a Salmonella.pdf | 1.139Mb | ![]() | Ver/ | |