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Artículo
A single gene for lycopene cyclase, phytoene synthase, and regulation of carotene biosynthesis in Phycomyces
dc.creator | Ávalos Cordero, Francisco Javier | |
dc.creator | Arrach, Nabil | |
dc.creator | Fernández Martín, Rafael | |
dc.creator | Cerdá Olmedo, Enrique | |
dc.date.accessioned | 2016-02-26T08:30:22Z | |
dc.date.available | 2016-02-26T08:30:22Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 0027-8424 | es |
dc.identifier.uri | http://hdl.handle.net/11441/36598 | |
dc.description.abstract | Previous complementation and mapping of mutations that change the usual yellow color of the Zygomycete Phycomyces blakesleea- nus to white or red led to the definition of two structural genes for carotene biosynthesis. We have cloned one of these genes, carRA, by taking advantage of its close linkage to the other, carB, respon- sible for phytoene dehydrogenase. The sequences of the wild type and six mutants have been established, compared with sequences in other organisms, and correlated with the mutant phenotypes. The carRA and carB coding sequences are separated by 1,381 untranslated nucleotides and are divergently transcribed. Gene carRA contains separate domains for two enzymes, lycopene cy- clase and phytoene synthase, and regulates the overall activity of the pathway and its response to physical and chemical stimuli from the environment. The lycopene cyclase domain of carRA derived from a duplication of a gene from a common ancestor of fungi and Brevibacterium linens; the phytoene synthase domain is similar to the phytoene and squalene synthases of many organisms; but the regulatory functions appear to be specific to Phycomyces | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America, 98, 1687-1692 | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Carotene | es |
dc.subject | Fungal enzyme | es |
dc.subject | Lycopene cyclase | es |
dc.subject | Oxidoreductase | es |
dc.subject | Phytoene synthase | es |
dc.subject | Squalene synthase | es |
dc.subject | Unclassified drug | es |
dc.title | A single gene for lycopene cyclase, phytoene synthase, and regulation of carotene biosynthesis in Phycomyces | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.publisherversion | 10.1073/pnas.98.4.1687 | es |
dc.identifier.doi | http://dx.doi.org/10.1073/pnas.98.4.1687 | es |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/36598 |
Ficheros | Tamaño | Formato | Ver | Descripción |
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A single gene for lycopene.pdf | 265.8Kb | [PDF] | Ver/ | |