Mostrar el registro sencillo del ítem
Artículo
Sucrose esters from Physalis peruviana calyces with anti-inflammatory activity
dc.creator | Espartero Sánchez, José Luis | |
dc.creator | Franco, Luis A. | |
dc.creator | Ocampo, Yanet C. | |
dc.creator | Gómez, Harold A. | |
dc.creator | Puerta Vázquez, Rocío de la | |
dc.creator | Ospina, Luis F. | |
dc.date.accessioned | 2016-02-17T08:29:26Z | |
dc.date.available | 2016-02-17T08:29:26Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0032-0943 | es |
dc.identifier.uri | http://hdl.handle.net/11441/34935 | |
dc.description.abstract | Physalis peruviana is a native plant from the South American Andes and is widely used in tra- ditional Colombian medicine of as an anti-inflam- matory medicinal plant, specifically the leaves, calyces, and small stems in poultice form. Pre- vious studies performed by our group on P. pe- ruviana calyces showed potent anti-inflamma- tory activity in an enriched fraction obtained from an ether total extract. The objective of the present study was to obtain and elucidate the ac- tive compounds from this fraction and evaluate their anti-inflammatory activity in vivo and in vi- tro. The enriched fraction of P. peruviana was pu- rified by several chromatographic methods to ob- tain an inseparable mixture of two new sucrose esters named peruviose A (1) and peruviose B (2). Structures of the new compounds were eluci- dated using spectroscopic methods and chemical transformations. The anti-inflammatory activity of the peruvioses mixture was evaluated using λ-carrageenan-induced paw edema in rats and lipopolysaccharide-activated peritoneal macro- phages. Results showed that the peruvioses did not produce side effects on the liver and kidneys and significantly attenuated the inflammation in- duced by λ-carrageenan in a dosage-dependent manner, probably due to an inhibition of nitric oxide and prostaglandin E2, which was demon- strated in vitro. To our knowledge, this is the first report of the presence of sucrose esters in P. pe- ruviana that showed a potent anti-inflammatory effect. These results suggest the potential of su- crose esters from the Physalis genus as a novel natural alternative to treat inflammatory diseases. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Georg Thieme Verlag | es |
dc.relation.ispartof | Planta Medica, 80, 1605-1614 | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Physalis peruviana | es |
dc.subject | Sucrose esters | es |
dc.subject | Solanaceae | es |
dc.subject | NO | es |
dc.subject | PGE2 | es |
dc.subject | TNF‑α | es |
dc.subject | Antiinflammatory activity | es |
dc.title | Sucrose esters from Physalis peruviana calyces with anti-inflammatory activity | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.publisherversion | 10.1055/s-0034-1383192 | es |
dc.relation.publisherversion | http://dx.doi.org/10.1055/s-0034-1383192 | es |
dc.identifier.doi | 10.1055/s-0034-1383192 | es |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/34935 |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Sucrose esters from physalis.pdf | 324.2Kb | [PDF] | Ver/ | |