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Mostrando ítems 1-10 de 11
Artículo
Risk Assessment and Environmental Consequences of the Use of the Allium-derived Compound Propyl-propane Thiosulfonate (PTSO) in Agrifood Applications
(Elsevier, 2023)
The organosulfur compound propyl-propane thiosulfonate (PTSO), mainly found in Allium cepa, has a promising use in the agrifood industry. To confirm its safety for livestock, consumers, and environment, toxicological ...
Artículo
Hydroxytyrosol and Dopamine Metabolites: Anti-aggregative Effect and Neuroprotective Activity Against α-synuclein-induced Toxicity
(Elsevier, 2023)
The abnormal aggregation of the α-synuclein (αsyn) protein is involved in the formation of Lewy bodies in the brain of patients suffering from Parkinson disease (PD). Hydroxytyrosol (HT), a polyphenolic compound present ...
Artículo
Simultaneous determination of Allium compounds (Propyl propane thiosulfonate and thiosulfinate) in animal feed using UPLC-MS/MS
(Elsevier, 2021-11)
Propyl-propane-thiosulfonate (PTSO) and Propyl-propane-thiosulfinate (PTS) are organosulfur compounds used to supplement the diet of livestock because of their beneficial effects on feed palatability, their antibacterial, ...
Artículo
Genotoxicity Evaluation of Two Derived Products from Allium Extracts: s-propylmercaptocysteine and s-propyl Mercaptoglutathione
(Elsevier, 2023)
Propyl-propane-thiosulfonate (PTSO) is one of the main organosulfur compounds present in Allium essential oils with a widely documented biological activity. For this reason, it could be used as a food and feed additive in ...
Artículo
Isotopic labelling-based analysis elucidates biosynthesis pathways in Saccharomyces cerevisiae for Melatonin, Serotonin and Hydroxytyrosol formation
(Elsevier, 2022)
Yeasts can synthetise bioactive compounds such as Melatonin (MEL), Serotonin (SER) and Hydroxytyrosol (HT). Deciphering the mechanisms involved in their formation can lead to exploit this fact to increase the bioactive ...
Artículo
Immunotoxic Effects Induced by Microcystins and Cylindrospermopsin: A Review
(MDPI, 2021)
Cyanotoxin occurrence is gaining importance due to anthropogenic activities, climate change and eutrophication. Among them, Microcystins (MCs) and Cylindrospermopsin (CYN) are the most frequently studied due to their ...
Artículo
Melatonin, Protocatechuic Acid and Hydroxytyrosol Effects on Vitagenes System Against Alpha-Synuclein Toxicity
(Elsevier, 2019)
Preventing the abnormal assembly of α-synuclein (α-Syn) and the correct modulation of vitagenes system exercise strong neuroprotective effects. It has been reported that melatonin (MEL), protocatechuic acid (PCA) and ...
Artículo
In Vitro Effects of Serotonin, Melatonin, and Other Related Indole Compounds on Amyloid-beta Kinetics and Neuroprotection
(Wiley, 2018)
Scope Amyloid-β peptide is the main component of senile plaques in Alzheimer's disease. The inhibition of amyloid-β peptide assembly, the destabilization of amyloid-β peptide aggregates, and the decrease of its cytotoxicity ...
Artículo
Genotoxic Effects of Cylindrospermopsin, Microcystin-LR and Their Binary Mixture in Human Hepatocellular Carcinoma (HepG2) Cell Line
(MDPI, 2020)
Simultaneous occurrence of cylindrospermopsin (CYN) and microcystin-LR (MCLR) has been reported in the aquatic environment and thus human exposure to such mixtures is possible. As data on the combined effects of CYN/MCLR ...
Artículo
Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
(MDPI, 2020)
Neuroinflammation is a common feature shared by neurodegenerative disorders, such as Parkinson’sdisease(PD),andseemstoplayakeyroleintheirdevelopmentandprogression. Microglia cells, the principal orchestrators of neuroinflammation, ...