dc.creator | Aroca Aguilar, Ángeles | es |
dc.creator | Yruela Guerrero, Inmaculada | es |
dc.creator | Gotor Martínez, Cecilia | es |
dc.creator | Bassham, Diane C. | es |
dc.date.accessioned | 2024-07-19T12:06:26Z | |
dc.date.available | 2024-07-19T12:06:26Z | |
dc.date.issued | 2021-05 | |
dc.identifier.citation | Aroca Aguilar, Á., Yruela Guerrero, I., Gotor Martínez, C. y Bassham, D.C. (2021). Persulfidation of ATG18a regulates autophagy underER stress in Arabidopsis. Proceedings of the National Academy of Sciences (PNAS), 118 (20), e2023604118. https://doi.org/10.1073/pnas.2023604118. | |
dc.identifier.issn | 0027-8424 | es |
dc.identifier.issn | 1091-6490 | es |
dc.identifier.uri | https://hdl.handle.net/11441/161577 | |
dc.description.abstract | Hydrogen sulfide (H2S) is an endogenously generated gaseous signaling molecule, which recently has been implicated in autophagy regulation in both plants and mammals through persulfidation of specific targets. Persulfidation has been suggested as the molecular mechanism through which sulfide regulates autophagy in plant cells. ATG18a is a core autophagy component that is required for bulk autophagy and also for reticulophagy during endoplasmic reticulum (ER) stress. In this research, we revealed the role of sulfide in plant ER stress responses as a negative regulator of autophagy. We demonstrate that sulfide regulates ATG18a phospholipid-binding activity by reversible persulfidation at Cys103, and that this modification activates ATG18a binding capacity to specific phospholipids in a reversible manner. Our findings strongly suggest that persulfidation of ATG18a at C103 regulates autophagy under ER stress, and that the impairment of persulfidation affects both the number and size of autophagosomes. | es |
dc.description.sponsorship | European Union’s Horizon 2020 No. 834120 | es |
dc.description.sponsorship | European Regional Development Fund Project US-1255781 | es |
dc.description.sponsorship | Agencia Estatal Investigación and European Regional Development Fund PID2019-109785GB-I00 | es |
dc.description.sponsorship | NIH Grant 1R01GM120316-01A1 | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | National Academy of Sciences | es |
dc.relation.ispartof | Proceedings of the National Academy of Sciences (PNAS), 118 (20), e2023604118. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | autophagy | es |
dc.subject | hydrogen sulfide | es |
dc.subject | ER stress | es |
dc.subject | ATG18a | es |
dc.subject | persulfidation | es |
dc.title | Persulfidation of ATG18a regulates autophagy underER stress in Arabidopsis | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular | es |
dc.relation.projectID | 834120 | es |
dc.relation.projectID | US-125578 | es |
dc.relation.projectID | PID2019-109785GB-I00 | es |
dc.relation.projectID | R01GM120316-01A1 | es |
dc.relation.publisherversion | https://dx.doi.org/10.1073/pnas.2023604118 | es |
dc.identifier.doi | 10.1073/pnas.2023604118 | es |
dc.journaltitle | Proceedings of the National Academy of Sciences (PNAS) | es |
dc.publication.volumen | 118 | es |
dc.publication.issue | 20 | es |
dc.publication.initialPage | e2023604118 | es |
dc.contributor.funder | European Union (UE). H2020 | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Agencia Estatal de Investigación. España | es |
dc.contributor.funder | National Institutes of Health. United States | es |