Artículo
Local and global changes in cell density induce reorganisation of 3D packing in a proliferating epithelium
Autor/es | Barone, Vanessa
Tagua Jáñez, Antonio Jesús Andrés San Román, Jesús Ángel Hamdoun, Amro Garrido García, Juan Lyons, Deirdre C. Escudero Cuadrado, Luis María |
Departamento | Universidad de Sevilla. Departamento de Biología Celular Universidad de Sevilla. Departamento de Matemática Aplicada I (ETSII) |
Fecha de publicación | 2024 |
Fecha de depósito | 2024-05-28 |
Publicado en |
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Resumen | Tissue morphogenesis is intimately linked to the changes in shape and organisation of individual cells. In curved epithelia, cells can intercalate along their own apicobasal axes, adopting a shape named ‘scutoid’ that ... Tissue morphogenesis is intimately linked to the changes in shape and organisation of individual cells. In curved epithelia, cells can intercalate along their own apicobasal axes, adopting a shape named ‘scutoid’ that allows energy minimization in the tissue. Although several geometric and biophysical factors have been associated with this 3D reorganisation, the dynamic changes underlying scutoid formation in 3D epithelial packing remain poorly understood. Here, we use live imaging of the sea star embryo coupled with deep learning-based segmentation to dissect the relative contributions of cell density, tissue compaction and cell proliferation on epithelial architecture. We find that tissue compaction, which naturally occurs in the embryo, is necessary for the appearance of scutoids. Physical compression experiments identify cell density as the factor promoting scutoid formation at a global level. Finally, the comparison of the developing embryo with computational models indicates that the increase in the proportion of scutoids is directly associated with cell divisions. Our results suggest that apico-basal intercalations appearing immediately after mitosis may help accommodate the new cells within the tissue. We propose that proliferation in a compact epithelium induces 3D cell rearrangements during development. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) Universidad de Sevilla Junta de Andalucía |
Identificador del proyecto | LT000070/2019
1R35GM133673 PID2019-103900GB-I00 AEI/10.13039/501100011033 PID2022-137101NBI00/AEI/10.13039/501100011033 US-1380953 PRE2020-093682 PY18-631 |
Cita | Barone, V., Tagua Jáñez, A.J., Andrés San Román, J.Á., Hamdoun, A., Garrido García, J., Lyons, .C. y Escudero Cuadrado, L.M. (2024). Local and global changes in cell density induce reorganisation of 3D packing in a proliferating epithelium. Development, 151(20) (dev202362). https://doi.org/10.1242/dev.202362. |
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