dc.creator | Coba, Cristóbal de la | es |
dc.creator | Argüelles Arias, Federico | es |
dc.creator | Martín de Argila, Carlos | es |
dc.creator | Júdez, Javier | es |
dc.creator | Linares, Antonio | es |
dc.creator | Ortega Alonso, Aida | es |
dc.creator | Rodríguez Téllez, Manuel José | es |
dc.creator | Giganto, Froilán | es |
dc.date.accessioned | 2024-05-22T14:51:55Z | |
dc.date.available | 2024-05-22T14:51:55Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Coba, C.d.l., Argüelles Arias, F., Martín de Argila, C., Júdez, J., Linares, A., Ortega Alonso, A.,...,Giganto, F. (2016). Proton-pump inhibitors adverse effects: a review of the evidence and position statement by the Sociedad Española de Patología Digestiva. Revista Española de Enfermedades Digestivas, 108 (4), 207-224. https://doi.org/10.17235/reed.2016.4232/2016. | |
dc.identifier.issn | 1130-0108 | es |
dc.identifier.issn | 2340-4167 | es |
dc.identifier.uri | https://hdl.handle.net/11441/158827 | |
dc.description.abstract | Introduction: In the last few years a significant number of
papers have related the use of proton-pump inhibitors (PPIs) to
potential serious adverse effects that have resulted in social unrest.
Objective: The goal of this paper was to provide a literature
review for the development of an institutional position statement
by Sociedad Española de Patología Digestiva (SEPD) regarding
the safety of long-term PPI use.
Material and methods: A comprehensive review of the
literature was performed to draw conclusions based on a critical
assessment of the following: a) current PPI indications; b) vitamin
B12 deficiency and neurological disorders; c) magnesium deficiency;
d) bone fractures; e) enteric infection and pneumonia; f) interactions
with thienopyridine derivatives; e) complications in cirrhotic
patients.
Results: Current PPI indications have remained unchanged
for years now, and are well established. A general screening
of vitamin B12 levels is not recommended for all patients on a
PPI; however, it does seem necessary that magnesium levels be
measured at therapy onset, and then monitored in subjects on other
drugs that may induce hypomagnesemia. A higher risk for bone
fractures is present, even though causality cannot be concluded for
this association. The association between PPIs and infection with
Clostridium difficile is mild to moderate, and the risk for pneumonia
is low. In patients with cardiovascular risk receiving thienopyridines
derivatives it is prudent to adequately consider gastrointestinal
and cardiovascular risks, given the absence of definitive evidence
regardin potential drug-drug interactions; if gastrointestinal risk is
found to be moderate or high, effective prevention should be in
place with a PPI. PPIs should be cautiously indicated in patients
with decompensated cirrhosis.
Conclusions: PPIs are safe drugs whose benefits outweigh
their potential side effects both short-term and long-term, provided
their indication, dosage, and duration are appropriate. | es |
dc.format | application/pdf | es |
dc.format.extent | 17 p. | es |
dc.language.iso | eng | es |
dc.publisher | Aran Ediciones S.A. | es |
dc.relation.ispartof | Revista Española de Enfermedades Digestivas, 108 (4), 207-224. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Proton-pump inhibitors | es |
dc.subject | Adverse effects | es |
dc.subject | Guidelines as topic | es |
dc.subject | Position statement | es |
dc.subject | SEPD | es |
dc.title | Proton-pump inhibitors adverse effects: a review of the evidence and position statement by the Sociedad Española de Patología Digestiva | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.reed.es/proton-pump-inhibitors-adverse-effects-a-review-of-the-evidence-and-position-statement-by-the-sociedad-espanola-de-patologia-digestiva1120 | es |
dc.identifier.doi | 10.17235/reed.2016.4232/2016 | es |
dc.journaltitle | Revista Española de Enfermedades Digestivas | es |
dc.publication.volumen | 108 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 207 | es |
dc.publication.endPage | 224 | es |