dc.creator | Cruz-Chamorro, Ivan | es |
dc.creator | Santos-Sanchez, Guillermo | es |
dc.creator | Bollati, Carlotta | es |
dc.creator | Bartolomei, Martina | es |
dc.creator | Capriotti, Anna Laura | es |
dc.creator | Cerrato, Andrea | es |
dc.creator | Millán-Linares, María del Carmen | es |
dc.creator | Carrillo Vico, Antonio | es |
dc.creator | Lammi, Carmen | es |
dc.date.accessioned | 2024-05-17T12:09:27Z | |
dc.date.available | 2024-05-17T12:09:27Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Cruz-Chamorro, I., Santos-Sanchez, G., Bollati, C., Bartolomei, M., Capriotti, A.L., Cerrato, A.,...,Lammi, C. (2023). Chemical and biological characterization of the DPP-IV inhibitory activity exerted by lupin (Lupinus angustifolius) peptides: From the bench to the bedside investigation. Food Chemistry, 426 (Volumen: 426 Número de artículo: 136458). https://doi.org/10.1016/j.foodchem.2023.136458. | |
dc.identifier.issn | 0308-8146 | es |
dc.identifier.issn | 1873-7072 | es |
dc.identifier.uri | https://hdl.handle.net/11441/158518 | |
dc.description.abstract | Dipeptidyl peptidase IV (DPP-IV) is considered a key target for the diabetes treatment, since it is involved in glucose metabolism. Although lupin protein consumption shown hypoglycemic activity, there is no evidence of its effect on DPP-IV activity. This study demonstrates that a lupin protein hydrolysate (LPH), obtained by hydrolysis with Alcalase, exerts anti-diabetic activity by modulating DPP-IV activity. In fact, LPH decreased DPP-IV activity in a cell-free and cell-based system. Contextually, Caco-2 cells were employed to identify LPH peptides that can be intestinally trans-epithelial transported. Notably, 141 different intestinally transported LPH sequences were identified using nano- and ultra-chromatography coupled to mass spectrometry. Hence, it was demonstrated that LPH modulated the glycemic response and the glucose concentration in mice, by inhibiting the DPP-IV. Finally, a beverage containing 1 g of LPH decreased DPP-IV activity and glucose levels in humans. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Food Chemistry, 426 (Volumen: 426 Número de artículo: 136458). | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Bioactive peptides | es |
dc.subject | Food clinical trial | es |
dc.subject | Glycemia | es |
dc.subject | Lupin peptides | es |
dc.subject | Diabetes | es |
dc.title | Chemical and biological characterization of the DPP-IV inhibitory activity exerted by lupin (Lupinus angustifolius) peptides: From the bench to the bedside investigation | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Instituto de Biomedicina de Sevilla (IBIS) | |
dc.relation.projectID | PC-0111-2016-0111 | es |
dc.relation.projectID | VIPPIT-2020-II.4 | es |
dc.relation.projectID | AGL2012-40247-C02-01 | es |
dc.relation.projectID | AGL2012-40247-C02-02 | es |
dc.relation.projectID | FPU13/01210 | es |
dc.relation.projectID | DOC_00587/2020 | es |
dc.relation.projectID | CTS160 | es |
dc.relation.projectID | FPU16/02339 | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0308814623010762?via%3Dihub | es |
dc.identifier.doi | 10.1016/j.foodchem.2023.136458 | es |
dc.journaltitle | Food Chemistry | es |
dc.publication.volumen | 426 | es |
dc.publication.issue | Volumen: 426 Número de artículo: 136458 | es |
dc.contributor.funder | Consejeria de Salud | es |
dc.contributor.funder | Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades, Junta de Andalucia | es |
dc.contributor.funder | Erasmus+ Mobility Programme | es |
dc.contributor.funder | Ministerio de Economia y Competitividad, Gobierno de Espana | es |
dc.contributor.funder | Ministerio de Educacion, Cultura y Deporte, Gobierno de Espana | es |
dc.contributor.funder | PAIDI Program from Junta de Andalucia | es |
dc.contributor.funder | Universidad de Sevilla | es |
dc.description.awardwinning | Premio Mensual Publicación Científica Destacada de la US. Facultad de Medicina | |