dc.creator | Berastegui-Cabrera, Judith | es |
dc.creator | Aguilar-Guisado, Manuela | es |
dc.creator | Crespo-Rivas, Juan Carlos | es |
dc.creator | López-Verdugo, Macarena | es |
dc.creator | Merino, Laura | es |
dc.creator | Escoresca-Ortega, Ana | es |
dc.creator | Barón-Franco, Bosco | es |
dc.creator | Pachón Díaz, Jerónimo | es |
dc.creator | Sánchez-Céspedes, Javier | es |
dc.date.accessioned | 2024-05-17T10:12:25Z | |
dc.date.available | 2024-05-17T10:12:25Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Berastegui-Cabrera, J., Aguilar-Guisado, M., Crespo-Rivas, J.C., López-Verdugo, M., Merino, L., Escoresca-Ortega, A.,...,Sánchez-Céspedes, J. (2023). Prepandemic viral community-acquired pneumonia: Diagnostic sensitivity and specificity of nasopharyngeal swabs and performance of clinical severity scores. Journal of Medical Virology, 95 (1), e28317. https://doi.org/10.1002/jmv.28317. | |
dc.identifier.issn | 0146-6615 | es |
dc.identifier.issn | 1096-9071(Electrónica) | es |
dc.identifier.uri | https://hdl.handle.net/11441/158496 | |
dc.description.abstract | The objectives of this work were to assess the diagnostic sensitivity and specificity of nasopharyngeal (NP) swabs for viral community-acquired pneumonia (CAP) and the performance of pneumonia severity index (PSI) and CURB-65 severity scores in the viral CAP in adults. A prospective observational cohort study of consecutive 341 hospitalized adults with CAP was performed between January 2018 and March 2020. Demographics, comorbidities, symptoms/signs, analytical data, severity scores, antimicrobials, and outcomes were recorded. Blood, NP swabs, sputum, and urine samples were collected at admission and assayed by multiplex real time-PCR, bacterial cultures, and Streptococcus pneumoniae and Legionella pneumophila antigens detection, to determine the etiologies and quantify the viral load. The etiology was identified in 174 (51.0%) patients, and in 85 (24.9%) it was viral, the most frequent rhinovirus and influenza virus. The sensitivity of viral detection in sputum (50.7%) was higher than in NP swabs (20.9%). Compared with sputum, the positive predictive value and specificity of NP swabs for viral diagnosis were 95.8% and 96.9%, respectively. Performance of PSI and CURB-65 scores in all CAP with etiologic diagnosis were as expected, with mortality associated with higher values, but they were not associated with mortality in patients with viral pneumonia. NP swabs have lower sensitivity but high specificity for the diagnosis of viral CAP in adults compared with sputum, reinforcing the use NP swabs for the diagnostic etiology work-up. The PSI and CURB-65 scores did not predict mortality in the viral CAP, suggesting that they need to be updated scores based on the identification of the etiological agent. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley | es |
dc.relation.ispartof | Journal of Medical Virology, 95 (1), e28317. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Clinical severity scores | es |
dc.subject | Endemic infection | es |
dc.subject | Infection | es |
dc.subject | Wabs sensitivity and specificity | es |
dc.subject | Respiratory tract | es |
dc.subject | Viral community-acquired pneumonia | es |
dc.title | Prepandemic viral community-acquired pneumonia: Diagnostic sensitivity and specificity of nasopharyngeal swabs and performance of clinical severity scores | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.projectID | CB21/13/00006 | es |
dc.relation.projectID | PI17/01055 | es |
dc.relation.projectID | REIPI RD16/0016/0009 | es |
dc.relation.projectID | C-0059-2018 | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/jmv.28317 | es |
dc.identifier.doi | 10.1002/jmv.28317 | es |
dc.journaltitle | Journal of Medical Virology | es |
dc.publication.volumen | 95 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | e28317 | es |
dc.contributor.funder | CIBER de Enfermedades Infecciosas (CIBERINFEC) | es |
dc.contributor.funder | European Development Regional Fund | es |
dc.contributor.funder | European Development Regional Fund "A way to achieve Europe", Operative program Intelligent Growth 2014-2020 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |
dc.contributor.funder | Instituto de Salud Carlos III, Subdireccion General de Redes y Centros de Investigacion Cooperativa, Ministry of Economy, Industry, and Competitiveness, Spanish Network for Research in Infectious Diseases | es |
dc.contributor.funder | Ministerio de Ciencia e Innovacion | es |
dc.contributor.funder | National Plan R+D+I 2013-2016 | es |
dc.contributor.funder | Servicio Andaluz de Salud, Junta de Andalucia, Spain | es |
dc.description.awardwinning | Premio Mensual Publicación Científica Destacada de la US. Facultad de Medicina | |