dc.creator | Calleja-Panero, José Luis | es |
dc.creator | Andrade, Raúl J. | es |
dc.creator | Bañares, Rafael | es |
dc.creator | Crespo, Javier | es |
dc.creator | Esteban, Rafael | es |
dc.creator | Jarque, Isidro | es |
dc.creator | Mingot Castellano, María Eva | es |
dc.creator | Romero Gómez, Manuel | es |
dc.creator | Shepherd, John | es |
dc.creator | Gil, Alicia | es |
dc.date.accessioned | 2024-05-10T15:09:48Z | |
dc.date.available | 2024-05-10T15:09:48Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Calleja-Panero, J.L., Andrade, R.J., Bañares, R., Crespo, J., Esteban, R., Jarque, I.,...,Gil, A. (2020). Management of chronic liver disease-associated severe thrombocytopenia in Spain: a view from the experts. Revista Española de Enfermedades Digestivas, 112 (10), 778-783. https://doi.org/10.17235/REED.2020.6895/2020. | |
dc.identifier.issn | 1130-0108 | es |
dc.identifier.issn | 2340-4167 | es |
dc.identifier.uri | https://hdl.handle.net/11441/158089 | |
dc.description.abstract | Background: chronic liver disease (CLD) patients often pres
ent thrombocytopenia (TCP) and when severe, it may pre
vent them from undergoing necessary invasive procedures
due to an increased bleeding risk. The lack of scientific evi
dence makes it impossible to determine key aspects of the
current management and associated healthcare burden of
these patients in Spain.
Purpose: to gain insight into the current situation of patients
with CLD-associated severe TCP undergoing invasive proce
dures in Spain, based on the experience of clinical experts.
Methods: national Delphi study involving 32 medical
experts.
Results: the estimated prevalence of CLD-associated severe
TCP is approximately 5,967, with an annual incidence of
1,148 new patients. Patients undergo a median of 1 (0-3)
invasive procedures/year. Platelet transfusions (PTs) are the
standard option to raise platelet counts and are associated
with significant burden. The achievement of target plate
let levels (≥ 50 x 109/l) after a transfusion is not routinely
measured. The lack of effectiveness and short life span of
transfused platelets can lead to procedure cancellations and
bleeding events, which potentially affect patient outcomes.
Adverse events occur in 1-25 % of patients, including mild
(febrile and allergic reactions) and severe events (e.g., trans fusion-related acute lung injury). Between 5-15 % of patients
are unfit to receive PTs and approximately 3 % are treated
off-label with thrombopoietin receptor agonists.
Conclusions: this study provides a snapshot of the current
situation in Spain, highlighting that the current manage
ment is poorly standardized and suboptimal in some cases.
The results suggest the benefit of developing a consensus
document to address some of these shortcomings and to
advance in the search for alternatives to PTs. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 p. | es |
dc.language.iso | eng | es |
dc.publisher | Aran Ediciones S.A. | es |
dc.relation.ispartof | Revista Española de Enfermedades Digestivas, 112 (10), 778-783. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Thrombocytopenia | es |
dc.subject | Chronic liver disease | es |
dc.subject | Plate let transfusion | es |
dc.subject | Delphi | es |
dc.subject | Epidemiology | es |
dc.subject | Treatment | es |
dc.subject | Thrombo poietin receptor agonists | es |
dc.title | Management of chronic liver disease-associated severe thrombocytopenia in Spain: a view from the experts | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.reed.es/ArticuloFicha.aspx?id=4799&hst=0&idR=89&tp=1 | es |
dc.identifier.doi | 10.17235/REED.2020.6895/2020 | es |
dc.journaltitle | Revista Española de Enfermedades Digestivas | es |
dc.publication.volumen | 112 | es |
dc.publication.issue | 10 | es |
dc.publication.initialPage | 778 | es |
dc.publication.endPage | 783 | es |