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Unlocking the Potential of Iron-Containing Mesoporous Bioactive Glasses: Orchestrating Osteogenic Differentiation in Bone Marrow Mesenchymal Stem Cells and Osteoblasts
dc.creator | Zhou, Tian | es |
dc.creator | Xu, Zeqian | es |
dc.creator | Sun, Haishui | es |
dc.creator | Beltrán, Ana M. | es |
dc.creator | Nawaz, Qaisar | es |
dc.creator | Sui, Baiyan | es |
dc.creator | Boccaccini, Aldo R. | es |
dc.creator | Zheng, Kai | es |
dc.date.accessioned | 2024-05-10T08:04:41Z | |
dc.date.available | 2024-05-10T08:04:41Z | |
dc.date.issued | 2024-05 | |
dc.identifier.issn | 0927-7757 | es |
dc.identifier.issn | 1873-4359 | es |
dc.identifier.uri | https://hdl.handle.net/11441/158048 | |
dc.description.abstract | Iron (Fe) is a crucial element in the human body, playing a significant role in bone metabolism. The release of Fe ions at bone defect sites can promote bone regeneration. In this study, we synthesized Fe-containing mesoporous bioactive glasses (Fe-MBGs) in SiO₂-CaO-Fe₂O₃ composition using a sol-gel method. Regardless of the amount of incorporated Fe₂O₃ (up to 5 mol%), the Fe-MBGs maintained a mesoporous structure, and the inclusion of Fe₂O₃ did not alter their amorphous characteristics. However, the presence of Fe₂O₃ led to a reduction in both pore volume and specific surface area of the Fe-MBGs. Notably, Fe-MBGs demonstrated degradability in physiological fluids and could sustain release of Si, Fe, and Ca ions. Higher concentrations of incorporated Fe₂O₃ were found to reduce the degradation of Fe-MBGs. All Fe-MBGs exhibited favorable bioactivity, as evidenced by the rapid formation of hydroxyapatite when exposed to simulated body fluid. Fe-MBGs also demonstrated concentration-dependent effects on BMSCs and Saos-2 cells. Extracts of Fe-MBGs at 0.1 and 1 mg/mL exhibited non-cytotoxicity and promoted cell proliferation. Additionally, extracts of Fe-MBGs at 1 mg/mL significantly enhanced the alkaline phosphatase activity of BMSCs and Saos-2 cells, along with an upregulation of the expression of osteogenesis-related genes. These findings unlock the significant potential of Fe-MBGs as functional biomaterials for bone regeneration applications. The controlled release of Fe ions from these mesoporous bioactive glasses orchestrates osteogenic differentiation in bone marrow mesenchymal stem cells and osteoblasts. | es |
dc.format | application/pdf | es |
dc.format.extent | 31 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Mesoporous bioactive glasses | es |
dc.subject | Iron | es |
dc.subject | Osteogenic differentiation | es |
dc.subject | Bone regeneration | es |
dc.title | Unlocking the Potential of Iron-Containing Mesoporous Bioactive Glasses: Orchestrating Osteogenic Differentiation in Bone Marrow Mesenchymal Stem Cells and Osteoblasts | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte | es |
dc.relation.projectID | VIIPPI | es |
dc.date.embargoEndDate | 2026-06-01 | |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0927775724010495?via%3Dihub | es |
dc.identifier.doi | 10.1016/j.colsurfa.2024.134188 | es |
dc.contributor.group | Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales | es |
dc.journaltitle | Colloids and Surfaces A: Physicochemical and Engineering Aspects | es |
dc.contributor.funder | Universidad de Sevilla | es |
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