Artículo
Randomized, double-blind, placebo-controlled clinical trial on the usefulness of probiotic Lactobacillus reuteri in bismuth-containing quadruple eradication therapy for infection with Helicobacter pylori
Autor/es | Moreno Márquez, Carolina
Fernández Álvarez, Paula Castro Laria, Luisa Argüelles Arias, Federico Caunedo Álvarez, Ángel Gómez Rodríguez, Blas José |
Departamento | Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2022 |
Fecha de depósito | 2024-04-29 |
Publicado en |
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Resumen | Introduction: the primary goal of this study was to com pare gastrointestinal symptom reduction in patients on
bismuth-containing quadruple eradication therapy sup plemented with Lactobacillus reuteri strains (DSM 17938 ... Introduction: the primary goal of this study was to com pare gastrointestinal symptom reduction in patients on bismuth-containing quadruple eradication therapy sup plemented with Lactobacillus reuteri strains (DSM 17938 and ATCC PTA 6475) or placebo. Materials and methods: this was a randomized, dou ble-blind, parallel-arm, placebo-controlled clinical trial. Patients received a first-line eradication regimen based on bismuth subcitrate potassium, metronidazole, tetracycline hydrochloride (three-in-one capsules) and omeprazole 40 mg twice a day for ten days, plus a probiotic or placebo tablet for 30 days. During follow-up, gastrointestinal symp toms were assessed using an evaluation scale (GSRS), and adverse events were collected at 0, 14, 28 and 56 days. Results: a total of 80 patients were included from Febru ary 2018 to May 2019 at a single site. Eradication thera py was effective in 85 % of patients, with no differences between treatment arms. In the group receiving the probi otic, abdominal pain decreased in 42 % of patients, com pared with 19 % in the control group (OR: 0.27; CI, 0.13-0.58; p < 0.001), and abdominal distension decreased in 25 % versus 17 % in the control group (OR: 0.24; IC, 0.19-0.84; p < 0.001); Conclusions: treatment with L. reuteri only reduced abdominal pain and distension. Further studies are needed to establish the role of probiotics as adjuvant therapy in H. pylori eradication. |
Cita | Moreno Márquez, C., Fernández Álvarez, P., Castro Laria, L., Argüelles Arias, F., Caunedo Álvarez, Á. y Gómez Rodríguez, B.J. (2022). Randomized, double-blind, placebo-controlled clinical trial on the usefulness of probiotic Lactobacillus reuteri in bismuth-containing quadruple eradication therapy for infection with Helicobacter pylori. Revista Española de Enfermedades Digestivas, 114 (2), 89-955. https://doi.org/10.17235/reed.2021.7931/2021. |
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