dc.creator | Zhang, Wen Ting | es |
dc.creator | Gil-Gómez, Antonio | es |
dc.creator | Liu, Chang Hai | es |
dc.creator | Gao, Shuai Shuai | es |
dc.creator | Romero Gómez, Manuel | es |
dc.date.accessioned | 2024-04-29T13:04:26Z | |
dc.date.available | 2024-04-29T13:04:26Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Zhang, W.T., Gil-Gómez, A., Liu, C.H., Gao, S.S. y Romero Gómez, M. (2022). Diagnostic accuracy of circulating microRNA in hepatitis B virus-related hepatocellular carcinoma: a meta-analysis based on Asian data. Revista Española de Enfermedades Digestivas, 114 (5), 280-288. https://doi.org/10.17235/reed.2021.8139/2021. | |
dc.identifier.issn | 1130-0108 | es |
dc.identifier.issn | 2340-4167 | es |
dc.identifier.uri | https://hdl.handle.net/11441/157261 | |
dc.description.abstract | Background and aim: hepatitis B virus (HBV) is the main risk
factor for hepatocellular carcinoma (HCC). We performed
a meta-analysis based on Asian data to evaluate the diag nostic accuracy of circulating microRNA as a non-invasive
biomarker in the diagnosis of HBV-related HCC.
Methods: a comprehensive literature search (updated to
May 12, 2021) in PubMed, Embase, Web of Science, Wan fang Database, and China National Knowledge Infrastruc ture (CNKI) was performed to identify eligible studies. The
sensitivity, specificity, positive likelihood ratio (PLR), nega tive likelihood ratio (NLR), diagnostic odds ratio (DOR), and
area under the curve (AUC) for diagnosing HBV-related HCC
were pooled in this meta-analysis. A subgroup analysis was
performed to explore heterogeneity, and Deeks’ funnel plot
was used to assess publication bias.
Results: a total of 19 articles including 32 studies were
included in the current meta-analysis. The overall sensitivi ty, specificity, PLR, NLR, DOR and AUC were 0.83 (95 % CI:
0.79 to 0.87), 0.78 (95 % CI: 0.73 to 0.83), 3.9 (95 % CI: 3.0 to
4.9), 0.21 (95 % CI: 0.16 to 0.27), 18 (95 % CI: 12 to 27) and
0.88 (95 % CI: 0.85 to 0.91), respectively. Subgroup analysis
shows that miRNA clusters with a large sample size showed
better diagnostic accuracy. Although there is no publication
bias, the research still has some limitations.
Conclusions: circulating miRNAs could serve as a potential
non-invasive biomarker in diagnosing HBV-related HCC in
Asian populations. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | Aran Ediciones S.A. | es |
dc.relation.ispartof | Revista Española de Enfermedades Digestivas, 114 (5), 280-288. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Hepatocellular carcinoma | es |
dc.subject | Hepatitis B virus | es |
dc.subject | MicroRNA | es |
dc.subject | Biomarkers | es |
dc.subject | Meta-analysis | es |
dc.title | Diagnostic accuracy of circulating microRNA in hepatitis B virus-related hepatocellular carcinoma: a meta-analysis based on Asian data | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.reed.es/ArticuloFicha.aspx?id=6218&hst=0&idR=108&tp=1 | es |
dc.identifier.doi | 10.17235/reed.2021.8139/2021 | es |
dc.contributor.group | Universidad de Sevilla. CTS532: Unidad de Hepatología (Sistema Sanitario Público de Andalucía. Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla) | es |
dc.journaltitle | Revista Española de Enfermedades Digestivas | es |
dc.publication.volumen | 114 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 280 | es |
dc.publication.endPage | 288 | es |