dc.creator | Miravitlles, Marc | es |
dc.creator | Huerta, Alicia | es |
dc.creator | Valle, Manuel | es |
dc.creator | García-Sidro, Patricia | es |
dc.creator | Forné, Carles | es |
dc.creator | Crespo, Carlos | es |
dc.creator | López-Campos Bodineau, José Luis | es |
dc.date.accessioned | 2024-04-23T15:26:07Z | |
dc.date.available | 2024-04-23T15:26:07Z | |
dc.date.issued | 2015-02-16 | |
dc.identifier.citation | Miravitlles, M., Huerta, A., Valle, M., García-Sidro, P., Forné, C., Crespo, C. y López-Campos Bodineau, J.L. (2015). Clinical variables impacting on the estimation of utilities in chronic obstructive pulmonary disease. International journal of chronic obstructive pulmonary disease, 10, 367-377. https://doi.org/10.2147/COPD.S76397. | |
dc.identifier.issn | 1176-9106 | es |
dc.identifier.uri | https://hdl.handle.net/11441/157045 | |
dc.description.abstract | Purpose: Health utilities are widely used in health economics as a measurement of an
individual’s preference and show the value placed on different health states over a specific
period. Thus, health utilities are used as a measure of the benefits of health interventions in
terms of quality-adjusted life years. This study aimed to determine the demographic and clinical
variables significantly associated with health utilities for chronic obstructive pulmonary disease
(COPD) patients.
Patients and methods: This was a multicenter, observational, cross-sectional study conducted between October 2012 and April 2013. Patients were aged 40 years, with spirometrically confirmed COPD. Utility values were derived from the preference-based generic
questionnaire EQ-5D-3L applying weighted Spanish societal preferences. Demographic and
clinical variables associated with utilities were assessed by univariate and multivariate linear
regression models.
Results: Three hundred and forty-six patients were included, of whom 85.5% were male. The
mean age was 67.9 (standard deviation [SD] =9.7) years and the mean forced expiratory volume in
1 second (%) was 46.2% (SD =15.5%); 80.3% were former smokers, and the mean smoking history was 54.2 (SD =33.2) pack-years. Median utilities (interquartile range) were 0.81 (0.26) with
a mean value of 0.73 (SD =0.29); 22% of patients had a utility value of 1 (ceiling effect) and 3.2%
had a utility value lower than 0. The factors associated with utilities in the multivariate analysis
were sex (beta =-0.084, 95% confidence interval [CI]: -0.154; -0.013 for females), number
of exacerbations the previous year (-0.027, 95% CI: -0.044; -0.010), and modified Medical
Research Council Dyspnea Scale (mMRC) score (-0.123 [95% CI: -0.185; -0.061], -0.231
[95% CI: -0.301; -0.161], and -0.559 [95% CI: -0.660; -0.458] for mMRC scores 2, 3, and
4 versus 1), all P0.05.
Conclusion: Multivariate analysis showed that female sex, frequent exacerbations, and an
increased level of dyspnea were the main factors associated with reduced utility values in
patients with COPD. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | Dove Medical Press LTD | es |
dc.relation.ispartof | International journal of chronic obstructive pulmonary disease, 10, 367-377. | |
dc.rights | Atribución-NoComercial 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | COPD | es |
dc.subject | Health utility | es |
dc.subject | Health-related quality of life | es |
dc.subject | Multivariate linear regression | es |
dc.title | Clinical variables impacting on the estimation of utilities in chronic obstructive pulmonary disease | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.contributor.affiliation | Instituto de Biomedicina de Sevilla (IBIS) | es |
dc.relation.publisherversion | https://www.dovepress.com/clinical-variables-impacting-on-the-estimation-of-utilities-in-chronic-peer-reviewed-fulltext-article-COPD | es |
dc.identifier.doi | 10.2147/COPD.S76397 | es |
dc.journaltitle | International journal of chronic obstructive pulmonary disease | es |
dc.publication.volumen | 10 | es |
dc.publication.initialPage | 367 | es |
dc.publication.endPage | 377 | es |