dc.creator | Burgos-Panadero, Rebeca | es |
dc.creator | Lucantoni, Federico | es |
dc.creator | Gamero-Sandemetrio, Esther | es |
dc.creator | Cruz Merino, Luis de la | es |
dc.creator | Álvaro, Tomás | es |
dc.creator | Noguera, Rosa | es |
dc.date.accessioned | 2024-03-08T17:41:59Z | |
dc.date.available | 2024-03-08T17:41:59Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Burgos-Panadero, R., Lucantoni, F., Gamero-Sandemetrio, E., Cruz Merino, L.d.l., Álvaro, T. y Noguera, R. (2019). The tumour microenvironment as an integrated framework to understand cancer biology. Cancer Letters, 461, 112-122. https://doi.org/10.1016/j.canlet.2019.07.010. | |
dc.identifier.issn | 0304-3835 | es |
dc.identifier.issn | 1872-7980 | es |
dc.identifier.uri | https://hdl.handle.net/11441/156033 | |
dc.description.abstract | Cancer cells all share the feature of being immersed in a complex environment with altered cell-cell/cell-ex tracellular element communication, physicochemical information, and tissue functions. The so-called tumour
microenvironment (TME) is becoming recognised as a key factor in the genesis, progression and treatment of
cancer lesions. Beyond genetic mutations, the existence of a malignant microenvironment forms the basis for a
new perspective in cancer biology where connections at the system level are fundamental. From this standpoint,
different aspects of tumour lesions such as morphology, aggressiveness, prognosis and treatment response can be
considered under an integrated vision, giving rise to a new field of study and clinical management. Nowadays,
somatic mutation theory is complemented with study of TME components such as the extracellular matrix,
immune compartment, stromal cells, metabolism and biophysical forces. In this review we examine recent
studies in this area and complement them with our own research data to propose a classification of stromal
changes. Exploring these avenues and gaining insight into malignant phenotype remodelling, could reveal better
ways to characterize this disease and its potential treatment. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier Ireland Ltd | es |
dc.relation.ispartof | Cancer Letters, 461, 112-122. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Biophysics | es |
dc.subject | Bioelectric | es |
dc.subject | Metabolism | es |
dc.subject | Cancer treatment | es |
dc.subject | Extracellular matrix | es |
dc.subject | Stromal classification | es |
dc.title | The tumour microenvironment as an integrated framework to understand cancer biology | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0304383519304069?via%3Dihub | es |
dc.identifier.doi | 10.1016/j.canlet.2019.07.010 | es |
dc.contributor.group | Universidad de Sevilla. CTS151: Bioquímica médica. | es |
dc.journaltitle | Cancer Letters | es |
dc.publication.volumen | 461 | es |
dc.publication.initialPage | 112 | es |
dc.publication.endPage | 122 | es |