dc.creator | Torres-Zurita, Alberto | es |
dc.creator | Vázquez Montero, Lucía | es |
dc.creator | Gallego López, Laura | es |
dc.creator | Mediano Rambla, María Dolores | es |
dc.creator | Cruz Merino, Luis de la | es |
dc.date.accessioned | 2024-03-04T14:20:32Z | |
dc.date.available | 2024-03-04T14:20:32Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Torres-Zurita, A., Vázquez Montero, L., Gallego López, L., Mediano Rambla, M.D. y Cruz Merino, L.d.l. (2023). Sarcoidosis-like reaction induced by immune checkpoint inhibitor in a patient with hepatocellular carcinoma: a case report. Frontiers in Immunology, 14, 01-04. https://doi.org/10.3389/fimmu.2023.1150128. | |
dc.identifier.issn | 1664-3224 | es |
dc.identifier.uri | https://hdl.handle.net/11441/155796 | |
dc.description.abstract | Nowadays, immune checkpoint inhibitors (ICI) have become the cornerstone of
treatment for many tumors, either as monotherapy or in combination with other
therapies. However, these drugs are associated with several new side effects that
need early detection. We present the case of a 41-year-old male patient who has
been diagnosed with advanced hepatocellular carcinoma (HCC) with metastatic
retroperitoneal lymph nodes and a subdiaphragmatic metastatic lesion,
undergoing second-line treatment with a combination of nivolumab and
ipilimumab. After completing four cycles, the patient was admitted to the
hospital due to intermittent fever and profuse sweating. A CT scan showed
multiple pathologically enlarged lymph nodes in several locations, raising
suspicion of disease progression. The patient’s clinical progress was favorable
after symptomatic treatment (antipyretics) and was discharged one week after
admission. Several days later, the patient complained about painful bilateral
ocular redness and was diagnosed with bilateral anterior uveitis. Further blood
tests showed elevated angiotensin-converting enzyme (ACE) levels of 67 U/L
(normal range: 8 – 52) and decreasing alpha-fetoprotein (AFP) levels of 698 ng/
mL (previously 1210 ng/mL), indicative of non-progression of the oncological
disease. Finally, an excisional biopsy confirmed the presence of non-necrotizing
granulomatous lymphadenitis, leading to the diagnosis of sarcoidosis-like
reaction (SLR) induced by immunotherapy as the etiology of the
polyadenopathy syndrome. SLR, although uncommon, is an adverse effect of
ICI treatment resulting from immune system dysregulation, which can mimic
disease progression. It is crucial to be aware of this adverse event and to
understand the optimal management approach. | es |
dc.format | application/pdf | es |
dc.format.extent | 4 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media S.A. | es |
dc.relation.ispartof | Frontiers in Immunology, 14, 01-04. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Hepatocellular carcinoma | es |
dc.subject | Immune-checkpoint inhibitor | es |
dc.subject | Nivolumab plus ipilimumab combination therapy | es |
dc.subject | Immune related adverse event (irAE) | es |
dc.subject | Sarcoidosis | es |
dc.title | Sarcoidosis-like reaction induced by immune checkpoint inhibitor in a patient with hepatocellular carcinoma: a case report | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1150128/full | es |
dc.identifier.doi | 10.3389/fimmu.2023.1150128 | es |
dc.contributor.group | Universidad de Sevilla. CTS151: Bioquímica médica. | es |
dc.journaltitle | Frontiers in Immunology | es |
dc.publication.volumen | 14 | es |
dc.publication.initialPage | 01 | es |
dc.publication.endPage | 04 | es |