dc.creator | Piulats, J. M. | es |
dc.creator | Watkins, C. | es |
dc.creator | Costa García, M. | es |
dc.creator | del Carpio, L. | es |
dc.creator | Piperno-Neumann, S. | es |
dc.creator | Rutkowski, P. | es |
dc.creator | Cruz Merino, Luis de la | es |
dc.creator | Nathan, P. | es |
dc.date.accessioned | 2024-02-29T16:20:39Z | |
dc.date.available | 2024-02-29T16:20:39Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Piulats, J.M., Watkins, C., Costa García, M., del Carpio, L., Piperno-Neumann, S., Rutkowski, P.,...,Nathan, P. (2024). Overall survival from tebentafusp versus nivolumab plus ipilimumab in first-line metastatic uveal melanoma: a propensity score-weighted analysis. Annals of oncology, 35 (3), 317-326. https://doi.org/10.1016/j.annonc.2023.11.013. | |
dc.identifier.issn | 0923-7534 | es |
dc.identifier.issn | 1569-8041 | es |
dc.identifier.uri | https://hdl.handle.net/11441/155708 | |
dc.description.abstract | Background: Tebentafusp demonstrated a superior overall survival (OS) benefit [hazard ratio (HR) 0.51] compared to
investigator’s choice (82% pembrolizumab) in a randomized, phase III trial (IMCgp100-202; N ¼ 378) in untreated
metastatic uveal melanoma (mUM). The 1-year OS rates for tebentafusp and pembrolizumab were 73% and 59%,
respectively. In the single-arm GEM1402 (N ¼ 52), the 1-year OS rate for nivolumab plus ipilimumab (NþI) in mUM
was 52%. Due to limitations in conducting randomized trials in mUM, we compared OS on tebentafusp or
pembrolizumab (IMCgp100-202) to NþI (GEM1402) in untreated mUM using propensity scoring methods.
Patients and methods: Analyses were adjusted using propensity score-based inverse probability of treatment weighting
(IPTW), balancing age, sex, baseline lactate dehydrogenase (LDH), baseline alkaline phosphatase, disease location,
Eastern Cooperative Oncology Group status, and time from primary diagnosis to metastasis. OS was assessed using
IPT-weighted KaplaneMeier and Cox proportional hazard models. Sensitivity analyses using alternative missing data
and weights methods were conducted.
Results: The primary IPTW analysis included 240 of 252 patients randomized to tebentafusp from IMCgp100-202 and 45
of 52 NþI-treated patients from GEM-1402. Key baseline covariates, including LDH, were generally well balanced before
weighting. The IPTW-adjusted OS favored tebentafusp, HR 0.52 [95% confidence interval (CI) 0.35-0.78]; 1-year OS was
73% for tebentafusp versus 50% for NþI. Sensitivity analyses showed consistent superior OS for tebentafusp with all
IPTW HRs 0.61. IPTW analysis of pembrolizumab versus NþI showed no significant difference in OS (HR 0.72; 95% CI
0.50-1.06).
Conclusions: Tebentafusp was previously shown to provide an OS benefit compared to checkpoint inhibitors or
chemotherapy in untreated mUM. Propensity score analysis demonstrated a similar OS benefit for tebentafusp
compared with NþI. These data further support tebentafusp as the standard of care in previously untreated human
leukocyte antigen (HLA)-A*02:01þ adult patients with mUM. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Oxford University Press | es |
dc.relation.ispartof | Annals of oncology, 35 (3), 317-326. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Ipilimumab | es |
dc.subject | Metastatic uveal melanoma | es |
dc.subject | Nivolumab | es |
dc.subject | Overall survival | es |
dc.subject | Propensity score-weighted analysis | es |
dc.subject | Tebentafusp | es |
dc.title | Overall survival from tebentafusp versus nivolumab plus ipilimumab in first-line metastatic uveal melanoma: a propensity score-weighted analysis | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0923753423051001?via%3Dihub | es |
dc.identifier.doi | 10.1016/j.annonc.2023.11.013 | es |
dc.contributor.group | Universidad de Sevilla. CTS151: Bioquímica médica. | es |
dc.journaltitle | Annals of oncology | es |
dc.publication.volumen | 35 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 317 | es |
dc.publication.endPage | 326 | es |