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Extended-spectrum beta-lactamase-producing and carbapenem-resistant enterobacterales bloodstream infection after solid organ transplantation: recent trends in epidemiology and therapeutic approaches
dc.creator | Pérez-Nadales, Elena | es |
dc.creator | Fernández-Ruiz, Mario | es |
dc.creator | Gutiérrez-Gutiérrez, Belén | es |
dc.creator | Pascual, Álvaro | es |
dc.creator | Rodríguez-Baño, Jesús | es |
dc.creator | Torre-Cisneros, Julian | es |
dc.date.accessioned | 2024-02-26T16:08:01Z | |
dc.date.available | 2024-02-26T16:08:01Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Pérez-Nadales, E., Fernández-Ruiz, M., Gutiérrez-Gutiérrez, B., Pascual, Á., Rodríguez-Baño, J. y Torre-Cisneros, J. (2022). Extended-spectrum beta-lactamase-producing and carbapenem-resistant enterobacterales bloodstream infection after solid organ transplantation: recent trends in epidemiology and therapeutic approaches. transplant infectious disease, 4 (2), e 138881. https://doi.org/10.1111/tid.13881. | |
dc.identifier.issn | 1398-2273 | es |
dc.identifier.issn | 1399-3062 | es |
dc.identifier.uri | https://hdl.handle.net/11441/155614 | |
dc.description.abstract | Background: Infections caused by multidrug-resistant gram-negative bacilli (MDR GNB), in particular extended-spectrum β-lactamase-producing (ESBL-E) and carbapenem-resistant Enterobacterales (CRE), pose a major threat in solid organ transplantation (SOT). Outcome prediction and therapy are challenging due to the scarcity of randomized clinical trials (RCTs) or well-designed observational studies focused on this population. Methods: Narrative review with a focus on the contributions provided by the ongoing multinational INCREMENT-SOT consortium (ClinicalTrials identifier NCT02852902) in the fields of epidemiology and clinical management. Results: The Spanish Society of Transplantation (SET), the Group for Study of Infection in Transplantation of the Spanish Society of Infectious Diseases and Clinical Microbi- ology (GESITRA-SEIMC), and the Spanish Network for Research in Infectious Diseases (REIPI) recently published their recommendations for the management of MDR GNB infections in SOT recipients. We revisit the SET/GESITRA-SEIMC/REIPI document tak- ing into consideration new evidence that emerged on the molecular epidemiology, prognostic stratification, and treatment of post-transplant ESBL-E and CRE infections. Results derived from the INCREMENT-SOT consortium may support the therapeu- tic approach to post-transplant bloodstream infection (BSI). The initiatives devoted to sparing the use of carbapenems in low-risk ESBL-E BSI or to repurposing existing non-β-lactam antibiotics for CRE in both non-transplant and transplant patients are reviewed, as well as the eventual positioning in the specific SOT setting of recently approved antibiotics. Conclusion: Due to the clinical complexity and relative rarity of ESBL-E and CRE infec- tions in SOT recipients, multinational cooperative efforts such as the INCREMENT- SOT Project should be encouraged. In addition, RCTs focused on post-transplant serious infection remain urgently needed. | es |
dc.format | application/pdf | es |
dc.format.extent | 19 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley-Blackwell | es |
dc.relation.ispartof | transplant infectious disease, 4 (2), e 138881. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Antibiotics | es |
dc.subject | Arbapenem-resistant Enterobacterales | es |
dc.subject | Extended-spectrum β-lactamase-producing Enterobacterales | es |
dc.subject | INCREMENT-SOT Project | es |
dc.subject | Solid organ transplantation | es |
dc.subject | Treatment | es |
dc.title | Extended-spectrum beta-lactamase-producing and carbapenem-resistant enterobacterales bloodstream infection after solid organ transplantation: recent trends in epidemiology and therapeutic approaches | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Sevilla | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1111/tid.13881 | es |
dc.identifier.doi | 10.1111/tid.13881 | es |
dc.journaltitle | transplant infectious disease | es |
dc.publication.volumen | 4 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | e 138881 | es |