dc.creator | Rivero-Pino, Fernando | es |
dc.creator | Grao Cruces, Elena | es |
dc.creator | López Enriquez, Soledad | es |
dc.creator | Alba Jiménez, Gonzalo | es |
dc.creator | Márquez Parada, Elvira | es |
dc.creator | Claro Cala, Carmen María | es |
dc.creator | Santa-María Pérez, Consuelo | es |
dc.creator | Montserrat de la Paz, Sergio | es |
dc.date.accessioned | 2024-02-22T14:43:46Z | |
dc.date.available | 2024-02-22T14:43:46Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Rivero-Pino, F., Grao Cruces, E., López Enriquez, S., Alba Jiménez, G., Márquez Parada, E., Claro Cala, C.M.,...,Montserrat de la Paz, S. (2023). Modulation of Beta-Amyloid-Activated Primary Human Neutrophils by Dietary Phenols from Virgin Olive Oil. Nutrients, 15 (4), 941. https://doi.org/10.3390/nu15040941. | |
dc.identifier.issn | 2072-6643 | es |
dc.identifier.uri | https://hdl.handle.net/11441/155482 | |
dc.description.abstract | The defense mechanism against harmful stimuli is inflammation. Indeed, neurodegenerative disorders can arise as a result of a persistent neuroinflammation. Beta-amyloid (Aβ1-42) is an
early trigger in the origination of Alzheimer’s disease, leading to synaptic and cognitive impairments.
Virgin olive oil (VOO) is correlated with a decreased risk of developing immune-inflammatory
disorders, but the potential effects of the phenolic fraction (PF) from VOO in the modulation of
neuroinflammatory processes in neutrophils remain unknown. In this study, we investigated the
ability of the PF to modulate the activation of Aβ1-42-stimulated primary human neutrophils, focusing
on the expression of gene and surface markers and the release of pro-inflammatory and chemoattractant mediators. Down-regulation of pro-inflammatory cytokine gene expression in Aβ1-42-treated
neutrophils, among other changes, was reported. Furthermore, pretreatment with PF prevented
neutrophil activation. The beneficial effects in the modulation of inflammatory responses show the
relevance of VOO to achieve a healthier diet that can help prevent inflammatory diseases. | es |
dc.format | application/pdf | es |
dc.format.extent | 14 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Nutrients, 15 (4), 941. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Hydroxytyrosol | es |
dc.subject | Immunonutrition | es |
dc.subject | Neuroinflammation | es |
dc.subject | Neutrophils | es |
dc.subject | Olive oil | es |
dc.subject | Phenols | es |
dc.title | Modulation of Beta-Amyloid-Activated Primary Human Neutrophils by Dietary Phenols from Virgin Olive Oil | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología, Pediatría y Radiología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.projectID | TED2021-130521A-I00 | es |
dc.relation.publisherversion | https://www.mdpi.com/2072-6643/15/4/941 | es |
dc.identifier.doi | 10.3390/nu15040941 | es |
dc.journaltitle | Nutrients | es |
dc.publication.volumen | 15 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 941 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación. España | es |