Melatonin protects mast cells against cytotoxicity mediated by chemical stimuli PMACI: Possible clinical use

Maldonado y Aibar, María Dolores; Garcia-Moreno, H.; Calvo Gutiérrez, Juan Ramón

doi:10.1016/j.jneuroim.2013.06.013

Artículo

dc.creator	Maldonado y Aibar, María Dolores	es
dc.creator	Garcia-Moreno, H.	es
dc.creator	Calvo Gutiérrez, Juan Ramón	es
dc.date.accessioned	2024-02-19T13:40:22Z
dc.date.available	2024-02-19T13:40:22Z
dc.date.issued	2013
dc.identifier.citation	Maldonado y Aibar, M.D., Garcia-Moreno, H. y Calvo Gutiérrez, J.R. (2013). Melatonin protects mast cells against cytotoxicity mediated by chemical stimuli PMACI: Possible clinical use. Journal Of Neuroimmunology, 262 (1-2), 62-65. https://doi.org/10.1016/j.jneuroim.2013.06.013.
dc.identifier.issn	0165-5728	es
dc.identifier.uri	https://hdl.handle.net/11441/155343
dc.description.abstract	Melatonin has documented cytoprotective effects on a wide variety of immune cells. The mechanism of action on mast cells (RBL-2H3) still remains in the dark. We found that melatonin significantly attenuated phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-induced cytotoxicity in a concentration and time-dependent manner. It appears that the effect of melatonin on mast cells is two-fold: dependent (MT1 and MT2) and independent membrane receptors. In conclusion, melatonin treatment reduced the cytotoxicity, mediated by PMACI, and could provide a useful therapeutic option in processes where an excessive activation of mast cells occurs.	es
dc.format	application/pdf	es
dc.format.extent	4 p.	es
dc.language.iso	eng	es
dc.publisher	Elsevier	es
dc.relation.ispartof	Journal Of Neuroimmunology, 262 (1-2), 62-65.
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Melatonin	es
dc.subject	RBL-2H3 mast cells	es
dc.subject	Cytoprotection	es
dc.subject	Immune system	es
dc.title	Melatonin protects mast cells against cytotoxicity mediated by chemical stimuli PMACI: Possible clinical use	es
dc.type	info:eu-repo/semantics/article	es
dc.type.version	info:eu-repo/semantics/acceptedVersion	es
dc.rights.accessRights	info:eu-repo/semantics/openAccess	es
dc.contributor.affiliation	Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología	es
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0165572813001720?via%3Dihub	es
dc.identifier.doi	10.1016/j.jneuroim.2013.06.013	es
dc.journaltitle	Journal Of Neuroimmunology	es
dc.publication.volumen	262	es
dc.publication.issue	1-2	es
dc.publication.initialPage	62	es
dc.publication.endPage	65	es

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