Article
Melatonin protects mast cells against cytotoxicity mediated by chemical stimuli PMACI: Possible clinical use
Author/s | Maldonado y Aibar, María Dolores
Garcia-Moreno, H. Calvo Gutiérrez, Juan Ramón |
Department | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología |
Publication Date | 2013 |
Deposit Date | 2024-02-19 |
Published in |
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Abstract | Melatonin has documented cytoprotective effects on a wide variety of immune cells. The mechanism of action on mast cells (RBL-2H3) still remains in the dark. We found that melatonin significantly attenuated
phorbol ... Melatonin has documented cytoprotective effects on a wide variety of immune cells. The mechanism of action on mast cells (RBL-2H3) still remains in the dark. We found that melatonin significantly attenuated phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-induced cytotoxicity in a concentration and time-dependent manner. It appears that the effect of melatonin on mast cells is two-fold: dependent (MT1 and MT2) and independent membrane receptors. In conclusion, melatonin treatment reduced the cytotoxicity, mediated by PMACI, and could provide a useful therapeutic option in processes where an excessive activation of mast cells occurs. |
Citation | Maldonado y Aibar, M.D., Garcia-Moreno, H. y Calvo Gutiérrez, J.R. (2013). Melatonin protects mast cells against cytotoxicity mediated by chemical stimuli PMACI: Possible clinical use. Journal Of Neuroimmunology, 262 (1-2), 62-65. https://doi.org/10.1016/j.jneuroim.2013.06.013. |
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