dc.creator | Retamar Gentil, Pilar | es |
dc.creator | Lopez-Prieto, MD | es |
dc.creator | Rodriguez-Lopez, F. | es |
dc.creator | Cueto López, Marina de | es |
dc.creator | Garcia, M.V. | es |
dc.creator | Gonzalez-Galan, V. | es |
dc.creator | Rodríguez-Baño, Jesús | es |
dc.date.accessioned | 2024-02-06T15:12:11Z | |
dc.date.available | 2024-02-06T15:12:11Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Retamar Gentil, P., Lopez-Prieto, M., Rodriguez-Lopez, F., Cueto López, M.d., Garcia, M.V., Gonzalez-Galan, V. y Rodríguez-Baño, J. (2014). Predictors of early mortality in very elderly patients with bacteremia: a prospective multicenter cohort. International Journal of Infectious Diseases, 26, 863-87. https://doi.org/10.1016/j.ijid.2014.04.029. | |
dc.identifier.issn | 1201-9712 | es |
dc.identifier.uri | https://hdl.handle.net/11441/154729 | |
dc.description.abstract | Objectives: The proportion of very elderly people in the population is increasing, and infectious diseases
in this patient group may present with specific characteristics. The objective of this study was to
investigate the outcome predictors of bacteremia among the very elderly.
Methods: This was a multicenter prospective cohort study of bloodstream infections (BSI) in patients
80 years old in 15 hospitals in Spain. The outcome variables were 14-day and 30-day mortality.
Multivariate analysis was performed.
Results: One hundred and twenty episodes were included. Mortality was 22% (n = 26) on day 14 and 28%
(n = 34) on day 30. In the univariate analysis, the variables associated with mortality were neutropenia,
recent surgery, Pitt score 2, intensive care unit (ICU) admission, severe sepsis or shock, and abdominal,
unknown, and respiratory tract sources. In themultivariate analysis, variables associated with mortality on
day 14 were high-risk source (abdominal, unknown, and respiratory tract sources; odds ratio (OR) 7.9, 95% confidence interval (CI) 1.8–33.9), Pitt score 2 (OR 5.6, 95% CI 1.3–23.3), inadequate empirical treatment
(OR 11.24, 95% CI 1.6–80.2), and severe sepsis or shock at presentation (OR 5.3, 95% CI 1.4–20.7); the
interaction between empiric treatment and high-risk source was significant. On day 30, mortality was
independently related to a high-risk source (OR 2.92, 95%CI 1.1–7.5) and presentation with severe sepsis or
shock (OR 3.81, 95% CI 1.2–12.4).
Conclusions: Presentation with severe sepsis or shock and a high-risk source of BSI were independent
predictors of 14-day and 30-day mortality. Inadequate empirical treatment was also a predictor of early
mortality in patients with a high-risk source | es |
dc.format | application/pdf | es |
dc.format.extent | 5 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | International Journal of Infectious Diseases, 26, 863-87. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Bacteremia | es |
dc.subject | Mortality | es |
dc.subject | Very elderly | es |
dc.title | Predictors of early mortality in very elderly patients with bacteremia: a prospective multicenter cohort | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1201971214015264?via%3Dihub | es |
dc.identifier.doi | 10.1016/j.ijid.2014.04.029 | es |
dc.journaltitle | International Journal of Infectious Diseases | es |
dc.publication.volumen | 26 | es |
dc.publication.initialPage | 863 | es |
dc.publication.endPage | 87 | es |