dc.creator | Jiménez Alonso, Julio José | es |
dc.creator | López Lázaro, Miguel | es |
dc.date.accessioned | 2024-01-08T09:07:29Z | |
dc.date.available | 2024-01-08T09:07:29Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Jiménez Alonso, J.J. y López Lázaro, M. (2023). Dietary Manipulation of Amino Acids for Cancer Therapy. NUTRIENTS, 15 (13), 2879. https://doi.org/10.3390/nu15132879. | |
dc.identifier.issn | 2072-6643 | es |
dc.identifier.uri | https://hdl.handle.net/11441/153003 | |
dc.description.abstract | Cancer cells cannot proliferate and survive unless they obtain sufficient levels of the 20 proteinogenic amino acids (AAs). Unlike normal cells, cancer cells have genetic and metabolic alterations that may limit their capacity to obtain adequate levels of the 20 AAs in challenging metabolic environments. However, since normal diets provide all AAs at relatively constant levels and ratios, these potentially lethal genetic and metabolic defects are eventually harmless to cancer cells. If we temporarily replace the normal diet of cancer patients with artificial diets in which the levels of specific AAs are manipulated, cancer cells may be unable to proliferate and survive. This article reviews in vivo studies that have evaluated the antitumor activity of diets restricted in or supplemented with the 20 proteinogenic AAs, individually and in combination. It also reviews our recent studies that show that manipulating the levels of several AAs simultaneously can lead to marked survival improvements in mice with metastatic cancers. | es |
dc.description.sponsorship | AMINOVITA PRJ201803388 | es |
dc.description.sponsorship | Junta de Andalucía 2017/CTS-657; 2019/CTS-657; 2021/CTS-657 | es |
dc.description.sponsorship | AMINOVITA | es |
dc.format | application/pdf | es |
dc.format.extent | 44 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | NUTRIENTS, 15 (13), 2879. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | cancer metabolism | es |
dc.subject | anticancer activity | es |
dc.subject | artificial diets | es |
dc.subject | in vivo | es |
dc.subject | essential amino acids | es |
dc.subject | non-essential amino acids | es |
dc.subject | restriction | es |
dc.subject | leucine | es |
dc.subject | methionine | es |
dc.subject | cysteine | es |
dc.subject | arginine | es |
dc.subject | glutamine | es |
dc.subject | asparagine | es |
dc.title | Dietary Manipulation of Amino Acids for Cancer Therapy | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.projectID | PRJ201803388 | es |
dc.relation.projectID | 2017/CTS-657; 2019/CTS-657; 2021/CTS-657 | es |
dc.relation.publisherversion | https://doi.org/10.3390/nu15132879 | es |
dc.identifier.doi | 10.3390/nu15132879 | es |
dc.journaltitle | NUTRIENTS | es |
dc.publication.volumen | 15 | es |
dc.publication.issue | 13 | es |
dc.publication.initialPage | 2879 | es |
dc.contributor.funder | AMINOVITA | es |
dc.contributor.funder | Junta de Andalucia | es |