dc.creator | Messina, Nicole L. | es |
dc.creator | Germano, Susie | es |
dc.creator | McElroy, Rebecca | es |
dc.creator | Rudraraju, Rajeev | es |
dc.creator | Bonnici, Rhian | es |
dc.creator | Pittet, Laure F. | es |
dc.creator | Toro López, María Dolores del | es |
dc.creator | Pascual Hernández, Álvaro | es |
dc.creator | Rodríguez-Baño, Jesús | es |
dc.date.accessioned | 2023-11-27T14:01:43Z | |
dc.date.available | 2023-11-27T14:01:43Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Messina, N.L., Germano, S., McElroy, R., Rudraraju, R., Bonnici, R., Pittet, L.F.,...,Rodríguez-Baño, J. (2022). Off-target effects of bacillus Calmette–Guerin vaccination on immune responses to SARS-CoV-2: implications for protection against severe COVID-19. Clinical and Translational Immunology, 11 (4), e1387. https://doi.org/10.1002/cti2.1387. | |
dc.identifier.issn | 2050-0068 | es |
dc.identifier.uri | https://hdl.handle.net/11441/151678 | |
dc.description.abstract | Background and objectives. Because of its beneficial off-target
effects against non-mycobacterial infectious diseases, bacillus
Calmette–Guerin (BCG) vaccination might be an accessible early
intervention to boost protection against novel pathogens.
Multiple epidemiological studies and randomised controlled trials
(RCTs) are investigating the protective effect of BCG against
coronavirus disease 2019 (COVID-19). Using samples from
participants in a placebo-controlled RCT aiming to determine
whether BCG vaccination reduces the incidence and severity of
COVID-19, we investigated the immunomodulatory effects of BCG
on in vitro immune responses to SARS-CoV-2. Methods. This study
used peripheral blood taken from participants in the multicentre
RCT and BCG vaccination to reduce the impact of COVID-19 on
healthcare workers (BRACE trial). The whole blood taken from
BRACE trial participants was stimulated with c-irradiated SARS CoV-2-infected or mock-infected Vero cell supernatant. Cytokine
responses were measured by multiplex cytokine analysis, and
single-cell immunophenotyping was made by flow cytometry.
Results. BCG vaccination, but not placebo vaccination, reduced
SARS-CoV-2-induced secretion of cytokines known to be associated
with severe COVID-19, including IL-6, TNF-a and IL-10. In addition,
BCG vaccination promoted an effector memory phenotype in both
CD4+ and CD8+ T cells, and an activation of eosinophils in response
to SARS-CoV-2. Conclusions. The immunomodulatory signature of BCG’s off-target effects on SARS-CoV-2 is consistent with a
protective immune response against severe COVID-19. | es |
dc.format | application/pdf | es |
dc.format.extent | 15 p. | es |
dc.language.iso | eng | es |
dc.publisher | WILEY | es |
dc.relation.ispartof | Clinical and Translational Immunology, 11 (4), e1387. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | COVID-19 | es |
dc.subject | BCG | es |
dc.subject | Cytokine | es |
dc.subject | T cell | es |
dc.subject | SARS-CoV-2 | es |
dc.subject | Immunoregulation | es |
dc.title | Off-target effects of bacillus Calmette–Guerin vaccination on immune responses to SARS-CoV-2: implications for protection against severe COVID-19 | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/cti2.1387 | es |
dc.identifier.doi | 10.1002/cti2.1387 | es |
dc.journaltitle | Clinical and Translational Immunology | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | e1387 | es |