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dc.creatorSantos García, Diegoes
dc.creatorDeus Fonticoba, Teresa dees
dc.creatorCores Bartolomé, Carloses
dc.creatorFeal Painceiras, Maríaes
dc.creatorSuárez Castro, Esteres
dc.creatorCanfield, Héctores
dc.creatorMir Rivera, Pabloes
dc.date.accessioned2023-11-14T16:03:23Z
dc.date.available2023-11-14T16:03:23Z
dc.date.issued2022
dc.identifier.citationSantos García, D., Deus Fonticoba, T.d., Cores Bartolomé, C., Feal Painceiras, M., Suárez Castro, E., Canfield, H. y Mir Rivera, P. (2022). Motor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson’s Disease Patients: A 2-Year Follow-Up Study. Diagnostics, 12 (5), 1147. https://doi.org/10.3390/diagnostics12051147.
dc.identifier.issn2075-4418es
dc.identifier.urihttps://hdl.handle.net/11441/150663
dc.description.abstractObjective: The aim of the present study was to analyze the progression of non-motor symptoms (NMS) burden in Parkinson’s disease (PD) patients regarding the development of motor fluctuations (MF). Methods: PD patients without MF at baseline, who were recruited from January 2016 to November 2017 (V0) and evaluated again at a 2-year follow-up (V2) from 35 centers of Spain from the COPPADIS cohort, were included in this analysis. MF development at V2 was defined as a score ≥ 1 in the item-39 of the UPDRS-Part IV, whereas NMS burden was defined according to the Non-motor Symptoms Scale (NMSS) total score. Results: Three hundred and thirty PD patients (62.67 ± 8.7 years old; 58.8% males) were included. From V0 to V2, 27.6% of the patients developed MF. The mean NMSS total score at baseline was higher in those patients who developed MF after the 2-year follow-up (46.34 ± 36.48 vs. 34.3 ± 29.07; p = 0.001). A greater increase in the NMSS total score from V0 to V2 was observed in patients who developed MF (+16.07 ± 37.37) compared to those who did not develop MF (+6.2 ± 25.8) (p = 0.021). Development of MF after a 2-year follow-up was associated with an increase in the NMSS total score (β = 0.128; p = 0.046) after adjustment to age, gender, years from symptoms onset, levodopa equivalent daily dose (LEDD) and the NMSS total score at baseline, and the change in LEDD from V0 to V2. Conclusions: In PD patients, the development of MF is associated with a greater increase in the NMS burden after a 2-year follow-up.es
dc.formatapplication/pdfes
dc.format.extent18 p.es
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofDiagnostics, 12 (5), 1147.
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBurdenes
dc.subjectFollow-upes
dc.subjectNon-motor symptomses
dc.subjectMotor fluctuationses
dc.subjectParkinson’s diseasees
dc.titleMotor Fluctuations Development Is Associated with Non-Motor Symptoms Burden Progression in Parkinson’s Disease Patients: A 2-Year Follow-Up Studyes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.publisherversionhttps://www.mdpi.com/2075-4418/12/5/1147es
dc.identifier.doi10.3390/diagnostics12051147es
dc.contributor.groupUniversidad de Sevilla. CTS630: Trastornos del movimiento.es
dc.journaltitleDiagnosticses
dc.publication.volumen12es
dc.publication.issue5es
dc.publication.initialPage1147es

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