dc.creator | Babich, Tanya | es |
dc.creator | Naucler, Pontus | es |
dc.creator | Valik, John Karlsson | es |
dc.creator | Giske, Christian G. | es |
dc.creator | Benito, Natividad | es |
dc.creator | Cardona, Ruben | es |
dc.creator | Rodríguez-Baño, Jesús | es |
dc.creator | Cueto López, Marina de | es |
dc.creator | Yahav, Dafna | es |
dc.date.accessioned | 2023-11-13T14:36:13Z | |
dc.date.available | 2023-11-13T14:36:13Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Babich, T., Naucler, P., Valik, J.K., Giske, C.G., Benito, N., Cardona, R.,...,Yahav, D. (2022). Duration of Treatment for Pseudomonas aeruginosa Bacteremia: a Retrospective Study. INFECTIOUS DISEASES AND THERAPY, 11 (4), 1505-1519. https://doi.org/10.1007/s40121-022-00657-1. | |
dc.identifier.issn | 2193-8229 | es |
dc.identifier.issn | 2193-6382 | es |
dc.identifier.uri | https://hdl.handle.net/11441/150565 | |
dc.description.abstract | Introduction: There is no consensus regarding
optimal duration of antibiotic therapy for
Pseudomonas aeruginosa bacteremia. We aimed
to evaluate the impact of short antibiotic
course. Methods: We present a retrospective multicen ter study including patients with P. aeruginosa
bacteremia during 2009–2015. We evaluated
outcomes of patients treated with short (6–-
10 days) versus long (11–15 days) antibiotic
courses. The primary outcome was a composite
of 30-day mortality or bacteremia recurrence
and/or persistence. Univariate and inverse
probability treatment-weighted (IPTW) adjusted multivariate analysis for the primary outcome was performed. To avoid immortal time bias,
the landmark method was used.
Results: We included 657 patients; 273
received a short antibiotic course and 384 a long
course. There was no significant difference in
baseline characteristics of patients. The com posite primary outcome occurred in 61/384
patients in the long-treatment group (16%)
versus 32/273 in the short-treatment group
(12%) (p = 0.131). Mortality accounted for
41/384 (11%) versus 25/273 (9%) of cases,
respectively. Length of hospital stay was signif icantly shorter in the short group [median
13 days, interquartile range (IQR) 9–21 days,
versus median 15 days, IQR 11–26 days,
p = 0.002]. Ten patients in the long group dis continued antibiotic therapy owing to adverse
events, compared with none in the short group.
On univariate and multivariate analyses, dura tion of therapy was not associated with the
primary outcome.
Conclusions: In this retrospective study, 6–-
10 days of antibiotic course for P. aeruginosa
bacteremia were as effective as longer courses in
terms of survival and recurrence. Shorter ther apy was associated with reduced length of stay
and less drug discontinuation. | es |
dc.format | application/pdf | es |
dc.format.extent | 15 p. | es |
dc.language.iso | eng | es |
dc.publisher | SPRINGER LONDON LTD | es |
dc.relation.ispartof | INFECTIOUS DISEASES AND THERAPY, 11 (4), 1505-1519. | |
dc.rights | Atribución-NoComercial 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Pseudomonas aeruginosa | es |
dc.subject | Bacteremia | es |
dc.subject | Antibiotics | es |
dc.subject | Duration | es |
dc.subject | Antimicrobial stewardship | es |
dc.title | Duration of Treatment for Pseudomonas aeruginosa Bacteremia: a Retrospective Study | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología | es |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s40121-022-00657-1 | es |
dc.identifier.doi | 10.1007/s40121-022-00657-1 | es |
dc.journaltitle | INFECTIOUS DISEASES AND THERAPY | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 1505 | es |
dc.publication.endPage | 1519 | es |