dc.creator | Sánchez, Manuel Anguita | es |
dc.creator | Marín, Francisco | es |
dc.creator | Masjuan, Jaime | es |
dc.creator | Cosín-Sales, Juan | es |
dc.creator | Vázquez Rodríguez, José Manuel | es |
dc.creator | Barrios, Vivencio | es |
dc.creator | Barón-Esquivias, Gonzalo | es |
dc.creator | Fernández, Marcelo Sanmartín | es |
dc.date.accessioned | 2023-10-25T13:41:28Z | |
dc.date.available | 2023-10-25T13:41:28Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Sánchez, M.A., Marín, F., Masjuan, J., Cosín-Sales, J., Vázquez Rodríguez, J.M., Barrios, V.,...,Fernández, M.S. (2022). Impact of heart failure on the clinical profile and outcomes in patients with atrial fibrillation treated with rivaroxaban. Data from the EMIR study. CARDIOLOGY JOURNAL, 29 (6), 936-947. https://doi.org/10.5603/CJ.a2022.0091. | |
dc.identifier.issn | 1897-5593 | es |
dc.identifier.uri | https://hdl.handle.net/11441/149903 | |
dc.description.abstract | Background: The aim of this study was to analyze the impact of the presence of heart failure (HF) on
the clinical profile and outcomes in patients with atrial fibrillation (AF) anticoagulated with rivaroxaban.
Methods: Observational and non-interventional study that included AF adults recruited from 79
Spanish centers, anticoagulated with rivaroxaban ≥ 6 months before inclusion. Data were analyzed
according to baseline HF status.
Results: Out of 1,433 patients, 326 (22.7%) had HF at baseline. Compared to patients without HF, HF
patients were older (75.3 ± 9.9 vs. 73.8 ± 9.6 years; p = 0.01), had more diabetes (36.5% vs. 24.3%;
p < 0.01), coronary artery disease (28.2% vs. 12.9%; p < 0.01), renal insufficiency (31.7% vs. 22.6%; p = 0.01), higher CHA2DS2-VASc (4.5 ± 1.6 vs. 3.2 ± 1.4; p < 0.01) and HAS-BLED (1.8 ± 1.1 vs.
1.5 ± 1.0; p < 0.01). After a median follow-up of 2.5 years, among HF patients, annual rates of stroke/
/systemic embolism/transient ischemic attack, major adverse cardiovascular events (MACE) (non-fatal
myocardial infarction, revascularization and cardiovascular death), cardiovascular death, and major
bleeding were 1.2%, 3.0%, 2.0%, and 1.4%, respectively. Compared to those patients without HF, HF patients had greater annual rates of MACE (3.0% vs. 0.5%; p < 0.01) and cardiovascular death (2.0% vs.
0.2%; p < 0.01), without significant differences regarding other outcomes, including thromboembolic or
bleeding events. Previous HF was an independent predictor of MACE (odds ratio 3.4; 95% confidence
interval 1.6–7.3; p = 0.002) but not for thromboembolic events or major bleeding.
Conclusions: Among AF patients anticoagulated with rivaroxaban, HF patients had a worse clinical
profile and a higher MACE risk and cardiovascular mortality. HF was independently associated with
the development of MACE, but not with thromboembolic events or major bleeding. (Cardiol J 2022; 29,
6: 936–947). | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | Via Medica | es |
dc.relation.ispartof | CARDIOLOGY JOURNAL, 29 (6), 936-947. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Atrial fibrillation | es |
dc.subject | Bleeding | es |
dc.subject | EMIR | es |
dc.subject | Heart failure | es |
dc.subject | MACE | es |
dc.subject | Rivaroxaban | es |
dc.subject | Stroke | es |
dc.title | Impact of heart failure on the clinical profile and outcomes in patients with atrial fibrillation treated with rivaroxaban. Data from the EMIR study | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://journals.viamedica.pl/cardiology_journal/article/view/90164 | es |
dc.identifier.doi | 10.5603/CJ.a2022.0091 | es |
dc.journaltitle | CARDIOLOGY JOURNAL | es |
dc.publication.volumen | 29 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 936 | es |
dc.publication.endPage | 947 | es |