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dc.creatorAydillo, Teresaes
dc.creatorEscalera, Albaes
dc.creatorStrohmeier, Shirines
dc.creatorAslam, Sadafes
dc.creatorSánchez Cespedes, Javieres
dc.creatorAyllon, Juanes
dc.creatorRoca-Oporto, Cristinaes
dc.creatorPérez-Romero, Pilares
dc.creatorMontejo, Migueles
dc.creatorGavalda, Joanes
dc.creatorMuñoz, Patriciaes
dc.creatorLópez-Medrano, Franciscoes
dc.creatorCarratala, Jordies
dc.creatorKrammer, Florianes
dc.creatorGarcía-Sastre, Adolfoes
dc.creatorCordero Matia, María Elisaes
dc.date.accessioned2023-09-20T14:59:47Z
dc.date.available2023-09-20T14:59:47Z
dc.date.issued2020
dc.identifier.citationAydillo, T., Escalera, A., Strohmeier, S., Aslam, S., Sánchez Cespedes, J., Ayllon, J.,...,Cordero Matia, M.E. (2020). Pre-existing hemagglutinin stalk antibodies correlate with protection of lower respiratory symptoms in flu-infected transplant patients. Cell Reports Medicine, 1 (8), 100130. https://doi.org/10.1016/j.xcrm.2020.100130.
dc.identifier.issn2666-3791es
dc.identifier.urihttps://hdl.handle.net/11441/149047
dc.description.abstractHemagglutination-inhibitory antibodies are usually highly strain specific with little effect on infection with drifted or shifted strains. The significance of broadly cross-reactive non-HAI anti-influenza antibodies against conserved domains of virus glycoproteins, such as the hemagglutinin (HA) stalk, is of great interest. We characterize a cohort of 40 H1N1pmd09 influenza-infected patients and identify lower respiratory symptoms (LRSs) as a predictor for development of pneumonia. A binomial logistic regression of log10 pre-existing antibody values shows that the probability of LRS occurrence decreased with increased anti-HA full-length and stalk antibody ELISA titers. However, a multilevel logistic regression model adjusted by other potential serocorrelates demonstrates that only antibodies directed against the stalk of HA correlate with protection from lower respiratory infection, limiting disease progression. Our predictive model indicates that a threshold of protective immunity based on broadly cross-reactive HA stalk antibodies could be feasible.es
dc.formatapplication/pdfes
dc.format.extent13 p.es
dc.language.isoenges
dc.publisherCell Press ( Elsevier)es
dc.relation.ispartofCell Reports Medicine, 1 (8), 100130.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectInfluenza antibodieses
dc.subjectCorrelates of protectiones
dc.subjectTransplant patientses
dc.subjectViral pneumoniaes
dc.titlePre-existing hemagglutinin stalk antibodies correlate with protection of lower respiratory symptoms in flu-infected transplant patientses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2666379120301725?via%3Dihubes
dc.identifier.doi10.1016/j.xcrm.2020.100130es
dc.journaltitleCell Reports Medicinees
dc.publication.volumen1es
dc.publication.issue8es
dc.publication.initialPage100130es

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