dc.creator | García Vílchez, Raquel | es |
dc.creator | Añazco Guenkova, Ana M. | es |
dc.creator | López, Judith | es |
dc.creator | Dietmann, Sabine | es |
dc.creator | Tomé, Mercedes | es |
dc.creator | Jimeno González, Sonia | es |
dc.creator | Azkargorta, Mikel | es |
dc.creator | Elortza, Félix | es |
dc.creator | Bárcena, Laura | es |
dc.creator | Huertas Sánchez, Pablo | es |
dc.creator | Blanco, Sandra | es |
dc.date.accessioned | 2023-09-18T17:05:52Z | |
dc.date.available | 2023-09-18T17:05:52Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | García Vílchez, R., Añazco Guenkova, A.M., López, J., Dietmann, S., Tomé, M., Jimeno González, S.,...,Blanco, S. (2023). N7-methylguanosine methylation of tRNAs regulates survival to stress in cancer. Oncogene. https://doi.org/10.1038/s41388-023-02825-0. | |
dc.identifier.issn | 0950-9232 | es |
dc.identifier.issn | 1476-5594 | es |
dc.identifier.uri | https://hdl.handle.net/11441/148988 | |
dc.description.abstract | Tumour progression and therapy tolerance are highly regulated and complex processes largely dependent on the plasticity of cancer cells and their capacity to respond to stress. The higher plasticity of cancer cells highlights the need for identifying targetable molecular pathways that challenge cancer cell survival. Here, we show that N7-guanosine methylation (m7G) of tRNAs, mediated by METTL1, regulates survival to stress conditions in cancer cells. Mechanistically, we find that m7G in tRNAs protects them from stress-induced cleavage and processing into 5’ tRNA fragments. Our analyses reveal that the loss of tRNA m7G methylation activates stress response pathways, sensitising cancer cells to stress. Furthermore, we find that the loss of METTL1 reduces tumour growth and increases cytotoxic stress in vivo. Our study uncovers the role of m7G methylation of tRNAs in stress responses and highlights the potential of targeting METTL1 to sensitise cancer cells to chemotherapy. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación SAF2016-78667-R, PID2019-111692RB-I00, PGC2018-096244-B-I00 | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad RYC-2014-16550 | es |
dc.description.sponsorship | Junta de Castilla y León CSI264P20 | es |
dc.description.sponsorship | Consejo Superior de Investigaciones Científicas 2021AEP005 | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | Springer Nature | es |
dc.relation.ispartof | Oncogene. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | N7-methylguanosine methylation of tRNAs regulates survival to stress in cancer | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.relation.projectID | SAF2016-78667-R | es |
dc.relation.projectID | PID2019-111692RB-I00 | es |
dc.relation.projectID | PGC2018-096244-B-I00 | es |
dc.relation.projectID | RYC-2014-16550 | es |
dc.relation.projectID | CSI264P20 | es |
dc.relation.projectID | BES-2017-080530 | es |
dc.relation.projectID | 2021AEP005 | es |
dc.relation.publisherversion | https://doi.org/10.1038/s41388-023-02825-0 | es |
dc.identifier.doi | 10.1038/s41388-023-02825-0 | es |
dc.journaltitle | Oncogene | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |
dc.contributor.funder | Junta de Castilla-León | es |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (CSIC) | es |