Article
Binge drinking leads to an oxidative and metabolic imbalance in skeletal muscle during adolescence in rats: endocrine repercussion
Author/s | Romero Herrera, Inés
Nogales Bueno, Fátima Díaz Castro, Javier Moreno Fernández, Jorge Gallego López, María del Carmen Ochoa, Julio J. Carreras Sánchez, Olimpia Ojeda Murillo, María Luisa |
Department | Universidad de Sevilla. Departamento de Fisiología |
Publication Date | 2023 |
Deposit Date | 2023-09-18 |
Published in |
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Abstract | Binge drinking (BD) is an especially pro-oxidant model of alcohol consumption, mainly used by adolescents. It has recently been related to the hepatic IR-process. Skeletal muscle is known to be involved in insulin action ... Binge drinking (BD) is an especially pro-oxidant model of alcohol consumption, mainly used by adolescents. It has recently been related to the hepatic IR-process. Skeletal muscle is known to be involved in insulin action and modulation through myokine secretion. However, there is no information on muscle metabolism and myokine secretion after BD exposure in adolescents. Two experimental groups of adolescent rats have been used: control and BD-exposed one. Oxidative balance, energy status and lipid, and protein metabolism have been analyzed in muscle, together with myokine serum levels (IL-6, myostatin, LIF, IL-5, fractalkine, FGF21, irisin, BDNF, FSTL1, apelin, FABP3, osteocrin, osteonectin (SPARC), and oncostatin). In muscle, BD affects the antioxidant enzyme balance leading to lipid and protein oxidation. Besides, it also increases the activation of AMPK and thus contributes to decrease SREBP1 and pmTOR and to increase FOXO3a expressions, promoting lipid and protein degradation. These alterations deeply affect the myokine secretion pattern. This is the first study to examine a general myokine response after exposure to BD. BD not only caused a detrimental imbalance in myokines related to muscle turnover, decreased those contributing to increase IR-process, decreased FST-1 and apelin and their cardioprotective function but also reduced the neuroprotective BDNF. Consequently, BD leads to an important metabolic and energetic disequilibrium in skeletal muscle, which contributes to exacerbate a general IR-process. |
Funding agencies | Junta de Andalucía |
Project ID. | 2021/CTS-193
2019/CTS-193 |
Citation | Romero Herrera, I., Nogales Bueno, F., Díaz Castro, J., Moreno Fernández, J., Gallego López, M.d.C., Ochoa, J.J.,...,Ojeda Murillo, M.L. (2023). Binge drinking leads to an oxidative and metabolic imbalance in skeletal muscle during adolescence in rats: endocrine repercussion. Journal of Physiology and Biochemistry. https://doi.org/10.1007/s13105-023-00983-z. |
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