dc.creator | Jiménez, María Dolores | es |
dc.creator | López-Ríos, Laura | es |
dc.creator | Pérez-Machín, Rubén | es |
dc.creator | Chirino, Ricardo | es |
dc.creator | Davis, Bárbara | es |
dc.creator | Talero Barrientos, Elena Mª | es |
dc.creator | Motilva Sánchez, Virginia | es |
dc.date.accessioned | 2023-08-30T08:28:26Z | |
dc.date.available | 2023-08-30T08:28:26Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Jiménez, M.D., López-Ríos, L., Pérez-Machín, R., Chirino, R., Davis, B., Talero Barrientos, E.M. y Motilva Sánchez, V. (2020). Xanthigen® reduces lipid deposition and improves stress resistance in Caenorhabditis elegans. Journal of Herbal Medicine Research, 5, 41. https://doi.org/10.28933/jhmr-2019-1805. | |
dc.identifier.issn | 2474-106X | es |
dc.identifier.uri | https://hdl.handle.net/11441/148553 | |
dc.description.abstract | Xanthigen® is a nutraceutical combination of two well-known
natural products, brown seaweed extract (rich in fucoxanthin)
and pomegranate seed oil (rich in punicic acid), and it has been
designed to use in weight management, in conjunction with a
calorie restricted diet. In the nematode Caenorhabditis elegans
Xanthigen® treatment caused a significant reduction in lipid
deposition in wild-type N2 (WT-N2) animals but not in sirt-2.1-de ficient strain, which raises the possibility that the prolipolytic or
anti-lipogenic effect of Xanthigen® in these animals is mediated
through Sirtuin 2.1 activation. This response has been well de scribed for Xanthigen® in cell cultures and other animal models.
In addition, Xanthigen® treatment conferred to both strains an in creased resistance to thermal and oxidative stress, which opens
the possibility that the effects of Xanthigen® are not mediated
solely by Sirtuin 2.1 activation. We therefore explored whether
Xanthigen® could activate diverse defence mechanisms such as
DAF-16 activation, or GST induction in response to xenobiotics,
by using the strains TJ356, CL2070 and CL2166, stably express ing Pdaf-16::GFP, Phsp-16.2::GFP and Pgst-4::GFP, respectively.
Xanthigen® treatment provoked neither DAF-16 translocation
to the nucleus nor increased expression of HSP16.2 and GST4,
which opens the possibility that different mechanisms other than
DAF-16 and those involved in xenobiotic responses, are activat ed by Xanthigen® and are capable of conferring to the nematode
an increased resistance to thermal or oxidative stress. | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | eSciPub LLC | es |
dc.relation.ispartof | Journal of Herbal Medicine Research, 5, 41. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Xanthigen® | es |
dc.subject | Fucoxanthin | es |
dc.subject | Punicic acid | es |
dc.subject | Caenorhabditis elegans | es |
dc.subject | sirtuin 2.1 | es |
dc.subject | lipid deposition | es |
dc.subject | thermal stress | es |
dc.subject | oxidative stress | es |
dc.title | Xanthigen® reduces lipid deposition and improves stress resistance in Caenorhabditis elegans | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.publisherversion | https://dx.doi.org/10.28933/jhmr-2019-1805 | es |
dc.identifier.doi | 10.28933/jhmr-2019-1805 | es |
dc.journaltitle | Journal of Herbal Medicine Research | es |
dc.publication.volumen | 5 | es |
dc.publication.initialPage | 41 | es |