dc.creator | Provencio, Mariano | es |
dc.creator | Cobo, Manuel | es |
dc.creator | Rodríguez Abreu, Delvys | es |
dc.creator | Calvo, Virginia | es |
dc.creator | Carcereny, Enric | es |
dc.creator | Cantero, Alexandra | es |
dc.creator | Bernabé-Caro, Reyes | es |
dc.creator | Torrente, Ana | es |
dc.date.accessioned | 2023-07-21T10:24:03Z | |
dc.date.available | 2023-07-21T10:24:03Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Provencio, M., Cobo, M., Rodríguez Abreu, D., Calvo, V., Carcereny, E., Cantero, A.,...,Torrente, A. (2022). Determination of essential biomarkers in lung cancer: a real-world data study in Spain with demographic, clinical, epidemiological and pathological characteristics. BMC Cancer, 22 (1), 732. https://doi.org/10.1186/s12885-022-09830-8. | |
dc.identifier.issn | 1471-2407 | es |
dc.identifier.uri | https://hdl.handle.net/11441/148152 | |
dc.description.abstract | Background: The survival of patients with lung cancer has substantially increased in the last decade by about 15%.
This increase is, basically, due to targeted therapies available for advanced stages and the emergence of immuno‑
therapy itself. This work aims to study the situation of biomarker testing in Spain.
Patients and methods: The Thoracic Tumours Registry (TTR) is an observational, prospective, registry‑based study
that included patients diagnosed with lung cancer and other thoracic tumours, from September 2016 to 2020. This
TTR study was sponsored by the Spanish Lung Cancer Group (GECP) Foundation, an independent, scientific, multidis‑
ciplinary oncology society that coordinates more than 550 experts and 182 hospitals across the Spanish territory.
Results: Nine thousand two hundred thirty‑nine patients diagnosed with stage IV non‑small cell lung cancer
(NSCLC) between 2106 and 2020 were analysed. 7,467 (80.8%) were non‑squamous and 1,772 (19.2%) were squa‑
mous. Tumour marker testing was performed in 85.0% of patients with non‑squamous tumours vs 56.3% in those
with squamous tumours (p‑value < 0.001). The global testing of EGFR, ALK, and ROS1 was 78.9, 64.7, 35.6% respec‑
tively, in non‑squamous histology. PDL1 was determined globally in the same period (46.9%), although if we focus
on the last 3 years it exceeds 85%. There has been a significant increase in the last few years of all determinations and
there are even close to 10% of molecular determinations that do not yet have targeted drug approval but will have it
in the near future. 4,115 cases had a positive result (44.5%) for either EGFR, ALK, KRAS, BRAF, ROS1, or high PDL1.
Conclusions: Despite the lack of a national project and standard protocol in Spain that regulates the determina‑
tion of biomarkers, the situation is similar to other European countries. Given the growing number of different determinations and their high positivity, national strategies are urgently needed to implement next‑generation
sequencing (NGS) in an integrated and cost‑effective way in lung cancer. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | BMC | es |
dc.relation.ispartof | BMC Cancer, 22 (1), 732. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Biomarkers | es |
dc.subject | Testing | es |
dc.subject | Metastatic lung cancer | es |
dc.subject | Targeted therapies | es |
dc.title | Determination of essential biomarkers in lung cancer: a real-world data study in Spain with demographic, clinical, epidemiological and pathological characteristics | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-09830-8 | es |
dc.identifier.doi | 10.1186/s12885-022-09830-8 | es |
dc.contributor.group | Universidad de Sevilla. CTS629: Oncología molecular y nuevas terapias. | es |
dc.journaltitle | BMC Cancer | es |
dc.publication.volumen | 22 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 732 | es |