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Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: Evidence in Parkinson's disease patients
dc.creator | Burguillos García, Miguel Ángel | es |
dc.creator | Hajji, Nabil | es |
dc.creator | Englund, Elisabet | es |
dc.creator | Persson, Annette | es |
dc.creator | Cenci, Maria Angela | es |
dc.creator | Machado, Alberto | es |
dc.creator | Cano, Josefina | es |
dc.creator | Joseph, Bertrand | es |
dc.creator | Venero Recio, José Luis | es |
dc.date.accessioned | 2023-07-07T11:19:35Z | |
dc.date.available | 2023-07-07T11:19:35Z | |
dc.date.issued | 2011-01 | |
dc.identifier.citation | Burguillos García, M.Á., Hajji, N., Englund, E., Persson, A., Cenci, M.A., Machado, A.,...,Venero Recio, J.L. (2011). Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: Evidence in Parkinson's disease patients. Neurobiology of Disease, 41 (1), 177-188. https://doi.org/10.1016/j.nbd.2010.09.005. | |
dc.identifier.issn | 0969-9961 | es |
dc.identifier.uri | https://hdl.handle.net/11441/147799 | |
dc.description.abstract | We show that intranigral lipopolysaccharide (LPS) injection, which provokes specific degeneration of DA neurons, induced caspase-3 activation in the rat ventral mesencephalon, which was mostly associated with glial cells. In contrast, nigral DA neurons exhibited AIF nuclear translocation in response to LPS. A significant decrease of the Bcl-2/Bax ratio in nigral tissue after LPS injection was observed. We next developed an in vitro co-culture system with the microglial BV2 and the DA neuronal MN9D murine cell lines. The silencing of caspase-3 or AIF by small interfering RNAs exclusively in the DA MN9D cells demonstrated the key role of AIF in the LPS-induced death of DA cells. In vivo chemical inhibition of caspases and poly(ADP-ribose)polymerase-1, an upstream regulator of AIF release and calpain, proved the central role of the AIF-dependent pathway in LPS-induced nigral DA cell death. We also observed nuclear translocation of AIF in the ventral mesencephalon of Parkinson's disease subjects. © 2010 Elsevier Inc. | es |
dc.description.sponsorship | Ministerio de Ciencia Y Tecnología (MCYT). España SAF 2006-04119; SAF 2009-13778 (JLV) | es |
dc.format | application/pdf | es |
dc.format.extent | 48 | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Neurobiology of Disease, 41 (1), 177-188. | |
dc.subject | Apoptosis | es |
dc.subject | Apoptosis-inducing factor | es |
dc.subject | Caspase 3 | es |
dc.subject | Dopamine | es |
dc.subject | Parkinson's disease | es |
dc.subject | Substantia nigra | es |
dc.title | Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: Evidence in Parkinson's disease patients | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/submittedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.projectID | SAF 2006-04119 | es |
dc.relation.projectID | SAF 2009-13778 (JLV) | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.nbd.2010.09.005 | es |
dc.identifier.doi | 10.1016/j.nbd.2010.09.005 | es |
dc.journaltitle | Neurobiology of Disease | es |
dc.publication.volumen | 41 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 177 | es |
dc.publication.endPage | 188 | es |
dc.contributor.funder | Ministerio de Ciencia Y Tecnología (MCYT). España | es |
Ficheros | Tamaño | Formato | Ver | Descripción |
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Elsevier___Burguillos_et_al.pdf | 12.53Mb | [PDF] | Ver/ | Artículo |
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