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Article
Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa
Author/s | Fonte, Luis
Acosta, Armando Sarmiento, María E. Norazmi, Mohd Nor Ginori, María Armas, Yaxsier de Calderón Sandubete, Enrique José |
Department | Universidad de Sevilla. Departamento de Medicina |
Publication Date | 2022 |
Deposit Date | 2023-07-04 |
Published in |
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Abstract | There is an increasing attention to the emerging health problem represented by the clinical
and functional long-term consequences of SARS-CoV-2 infection, referred to as postacute COVID-19
syndrome. Clinical, radiographic, ... There is an increasing attention to the emerging health problem represented by the clinical and functional long-term consequences of SARS-CoV-2 infection, referred to as postacute COVID-19 syndrome. Clinical, radiographic, and autopsy findings have shown that a high rate of fibrosis and restriction of lung function are present in patients who have recovered from COVID-19. Patients with active TB, or those who have recovered from it, have fibrotic scarred lungs and, consequently, some degree of impaired respiratory function. Helminth infections trigger predominantly type 2 immune responses and the release of regulatory and fibrogenic cytokines, such as TGF-β. Here, we analyze the possible consequences of the overlapping of pulmonary fibrosis secondary to COVID-19 and tuberculosis in the setting of sub-Saharan Africa, the region of the world with the highest prevalence of helminth infection. |
Citation | Fonte, L., Acosta, A., Sarmiento, M.E., Norazmi, M.N., Ginori, M., Armas, Y.d. y Calderón Sandubete, E.J. (2022). Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa. TROPICAL MEDICINE AND INFECTIOUS DISEASE, 7 (8), 157. https://doi.org/10.3390/tropicalmed7080157. |
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