dc.creator | Alba Jiménez, Gonzalo | es |
dc.creator | Dakhaoui, Hala | es |
dc.creator | Santa-María Pérez, Consuelo | es |
dc.creator | Palomares, Francisca | es |
dc.creator | Cejudo Guillén, Marta | es |
dc.creator | Geniz, Isabel | es |
dc.creator | Sobrino, Francisco | es |
dc.creator | Montserrat de la Paz, Sergio | es |
dc.creator | López Enriquez, Soledad | es |
dc.date.accessioned | 2023-06-13T13:13:39Z | |
dc.date.available | 2023-06-13T13:13:39Z | |
dc.date.issued | 2023-01-13 | |
dc.identifier.issn | 2072-6643 | es |
dc.identifier.uri | https://hdl.handle.net/11441/147170 | |
dc.description.abstract | Nutraceuticals act as cellular and functional modulators, contributing to the homeostasis of
physiological processes. In an inflammatory microenvironment, these functional foods can interact
with the immune system by modulating or balancing the exacerbated proinflammatory response. In
this process, immune cells, such as antigen-presenting cells (APCs), identify danger signals and, after
interacting with T lymphocytes, induce a specific effector response. Moreover, this conditions their
change of state with phenotypical and functional modifications from the resting state to the activated
and effector state, supposing an increase in their energy requirements that affect their intracellular
metabolism, with each immune cell showing a unique metabolic signature. Thus, nutraceuticals,
such as polyphenols, vitamins, fatty acids, and sulforaphane, represent an active option to use
therapeutically for health or the prevention of different pathologies, including obesity, metabolic
syndrome, and diabetes. To regulate the inflammation associated with these pathologies, intervention
in metabolic pathways through the modulation of metabolic energy with nutraceuticals is an attractive
strategy that allows inducing important changes in cellular properties. Thus, we provide an overview
of the link between metabolism, immune function, and nutraceuticals in chronic inflammatory
processes associated with obesity and diabetes, paying particular attention to nutritional effects on
APC and T cell immunometabolism, as well as the mechanisms required in the change in energetic
pathways involved after their activation. | es |
dc.format | application/pdf | es |
dc.format.extent | 23 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Tolerogenic dendritic cells | es |
dc.subject | Macrophages | es |
dc.subject | Regulatory T cells | es |
dc.subject | Regulatory B cells | es |
dc.subject | Proteosome | es |
dc.subject | Autophagy | es |
dc.subject | Succinate | es |
dc.subject | Glycolysis | es |
dc.subject | Oxidative phosphorylation | es |
dc.subject | Tricarboxylic acid cycle | es |
dc.title | Nutraceuticals as potential therapeutic modulators in immunometabolism | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología, Pediatría y Radiología | es |
dc.relation.projectID | Grant Proyect-202200000421 | es |
dc.relation.publisherversion | https://www.mdpi.com/2072-6643/15/2/411 | es |
dc.identifier.doi | 10.3390/nu15020411 | es |
dc.journaltitle | NUTRIENTS | es |
dc.publication.volumen | 15 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 411 | es |
dc.contributor.funder | VII Plan Propio de Investigación y Transferencia Universidad de Sevilla, España | es |