Article
Nutraceuticals as potential therapeutic modulators in immunometabolism
Author/s | Alba Jiménez, Gonzalo
Dakhaoui, Hala Santa-María Pérez, Consuelo Palomares, Francisca Cejudo Guillén, Marta Geniz, Isabel Sobrino, Francisco Montserrat de la Paz, Sergio López Enriquez, Soledad |
Department | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología Universidad de Sevilla. Departamento de Farmacología, Pediatría y Radiología |
Publication Date | 2023-01-13 |
Deposit Date | 2023-06-13 |
Abstract | Nutraceuticals act as cellular and functional modulators, contributing to the homeostasis of
physiological processes. In an inflammatory microenvironment, these functional foods can interact
with the immune system by ... Nutraceuticals act as cellular and functional modulators, contributing to the homeostasis of physiological processes. In an inflammatory microenvironment, these functional foods can interact with the immune system by modulating or balancing the exacerbated proinflammatory response. In this process, immune cells, such as antigen-presenting cells (APCs), identify danger signals and, after interacting with T lymphocytes, induce a specific effector response. Moreover, this conditions their change of state with phenotypical and functional modifications from the resting state to the activated and effector state, supposing an increase in their energy requirements that affect their intracellular metabolism, with each immune cell showing a unique metabolic signature. Thus, nutraceuticals, such as polyphenols, vitamins, fatty acids, and sulforaphane, represent an active option to use therapeutically for health or the prevention of different pathologies, including obesity, metabolic syndrome, and diabetes. To regulate the inflammation associated with these pathologies, intervention in metabolic pathways through the modulation of metabolic energy with nutraceuticals is an attractive strategy that allows inducing important changes in cellular properties. Thus, we provide an overview of the link between metabolism, immune function, and nutraceuticals in chronic inflammatory processes associated with obesity and diabetes, paying particular attention to nutritional effects on APC and T cell immunometabolism, as well as the mechanisms required in the change in energetic pathways involved after their activation. |
Funding agencies | VII Plan Propio de Investigación y Transferencia Universidad de Sevilla, España |
Project ID. | Grant Proyect-202200000421 |
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