dc.creator | Juanes Velasco, Pablo | es |
dc.creator | García-Vaquero, Marina L. | es |
dc.creator | Landeira Viñuela, Alicia | es |
dc.creator | López-Campos Bodineau, José Luis | es |
dc.creator | Marín, Carmen | es |
dc.creator | Lecrevisse, Quentin | es |
dc.creator | Arias Hidalgo, Carlota | es |
dc.creator | Montalvillo, Enrique | es |
dc.creator | Góngora, Rafael | es |
dc.creator | Hernández, Ángela Patricia | es |
dc.creator | Fuentes, Manuel | es |
dc.date.accessioned | 2023-06-06T13:56:48Z | |
dc.date.available | 2023-06-06T13:56:48Z | |
dc.date.issued | 2022-09-28 | |
dc.identifier.citation | Juanes Velasco, P., García-Vaquero, M.L., Landeira Viñuela, A., López-Campos Bodineau, J.L., Marín, C., Lecrevisse, Q.,...,Fuentes, M. (2022). Systematic evaluation of plasma signaling cascades by functional proteomics approaches SARS-CoV-2 infection as model. Proteomics: Clinical Applications, 16 (6), 2100100. https://doi.org/10.1002/prca.202100100. | |
dc.identifier.issn | 1862-8346; 1862-8354 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146970 | |
dc.description.abstract | Purpose
Acute phase reactants (APRs) play a critical role in inflammation. The difference in their physiological functions or the different dynamic ranges of these proteins in plasma makes it difficult to detect them simultaneously and to use several of these proteins as a tool in clinical practice.
Experimental Design
A novel multiplex assay has been designed and optimized to carry out a high-throughput and simultaneous screening of APRs, allowing the detection of each of them at the same time and in their corresponding dynamic range.
Results
Using Sars-CoV-2 infection as a model, it has been possible to profile different patterns of acute phase proteins that vary significantly between healthy and infected patients. In addition, severity profiles (acute respiratory distress syndrome and sepsis) have been established.
Conclusions and Clinical Relevance
Differential profiles in acute phase proteins can serve as a diagnostic and prognostic tool, among patient stratification. The design of this new platform for their simultaneous detection paves the way for them to be more extensive use in clinical practice. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley | es |
dc.relation.ispartof | Proteomics: Clinical Applications, 16 (6), 2100100. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | acute phase reactant | es |
dc.subject | antibody | es |
dc.subject | COVID-19 | es |
dc.subject | Functional proteomics | es |
dc.subject | high-throughput screening | es |
dc.subject | immune system | es |
dc.subject | inflammation | es |
dc.subject | microarray | es |
dc.title | Systematic evaluation of plasma signaling cascades by functional proteomics approaches SARS-CoV-2 infection as model | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.projectID | FIS PI18/00682 | es |
dc.relation.projectID | FIS PI21/01545 | es |
dc.relation.projectID | CB16/12/00400 | es |
dc.relation.projectID | PT17/0019/0023 | es |
dc.relation.projectID | JCYL-EDU/601/2020 | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/prca.202100100 | es |
dc.identifier.doi | 10.1002/prca.202100100 | es |
dc.journaltitle | Proteomics: Clinical Applications | es |
dc.publication.volumen | 16 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 2100100 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Junta de Castilla-León | es |