dc.creator | Guisado Gil, Ana Belén | es |
dc.creator | Infante Domínguez, Carmen | es |
dc.creator | Peñalva, Germán | es |
dc.creator | Praena, Julia | es |
dc.creator | Roca, Cristina | es |
dc.creator | Navarro Amuedo, María Dolores | es |
dc.creator | Romero Rodríguez, Nieves | es |
dc.creator | Lepe Jiménez, José Antonio | es |
dc.creator | Cisneros Herreros, José Miguel | es |
dc.date.accessioned | 2023-06-06T06:41:52Z | |
dc.date.available | 2023-06-06T06:41:52Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Guisado Gil, A.B., Infante Domínguez, C., Peñalva, G., Praena, J., Roca, C., Navarro Amuedo, M.D.,...,Cisneros Herreros, J.M. (2020). Impact of the COVID-19 pandemic on antimicrobial consumption and hospital-acquired candidemia and multidrug-resistant bloodstream infections. Antibiotics, 9 (11), 1-11. https://doi.org/10.3390/antibiotics9110816. | |
dc.identifier.issn | 2079-6382 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146936 | |
dc.description.abstract | During the COVID-19 pandemic, the implementation of antimicrobial stewardship strategies has been recommended. This study aimed to assess the impact of the COVID-19 pandemic in a tertiary care Spanish hospital with an active ongoing antimicrobial stewardship programme (ASP). For a 20-week period, we weekly assessed antimicrobial consumption, incidence density, and crude death rate per 1000 occupied bed days of candidemia and multidrug-resistant (MDR) bacterial bloodstream infections (BSI). We conducted a segmented regression analysis of time series. Antimicrobial consumption increased +3.5% per week (p = 0.016) for six weeks after the national lockdown, followed by a sustained weekly reduction of −6.4% (p = 0.001). The global trend for the whole period was stable. The frequency of empirical treatment of patients with COVID-19 was 33.7%. No change in the global trend of incidence of hospital-acquired candidemia and MDR bacterial BSI was observed (+0.5% weekly; p = 0.816), nor differences in 14 and 30-day crude death rates (p = 0.653 and p = 0.732, respectively). Our work provides quantitative data about the pandemic effect on antimicrobial consumption and clinical outcomes in a centre with an active ongoing institutional and education-based ASP. However, assessing the long-term impact of the COVID-19 pandemic on antimicrobial resistance is required. | es |
dc.description.sponsorship | Junta de Andalucía PI0361-2010 | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Antibiotics, 9 (11), 1-11. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | COVID-19 | es |
dc.subject | Antimicrobial stewardship | es |
dc.subject | Anti-infective agents | es |
dc.subject | Bacteremia | es |
dc.subject | Candidemia | es |
dc.title | Impact of the COVID-19 pandemic on antimicrobial consumption and hospital-acquired candidemia and multidrug-resistant bloodstream infections | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología | es |
dc.identifier.doi | 10.3390/antibiotics9110816 | es |
dc.contributor.group | Universidad de Sevilla. CTS-203: Estudio de las Enfermedades Infecciosas | es |
dc.contributor.group | Universidad de Sevilla. CTS-204: Biotecnología Aplicada al Estudio de Enfermedades Infecciosas | es |
dc.journaltitle | Antibiotics | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 11 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 11 | es |