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Potential Survival Benefit for Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation after Nivolumab Therapy for Relapse/Refractory Hodgkin Lymphoma: Real-Life Experience in Spain
dc.creator | Martínez, Carmen | es |
dc.creator | Corral Carpio, Cecilia | es |
dc.creator | Heras, Inmaculada | es |
dc.creator | Ríos Herranz, Eduardo | es |
dc.creator | Buch, Joan | es |
dc.creator | Gutierrez, Antonio | es |
dc.creator | García-Sanz, Ramón | es |
dc.date.accessioned | 2023-05-26T14:53:15Z | |
dc.date.available | 2023-05-26T14:53:15Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Martínez, C., Corral Carpio, C., Heras, I., Ríos Herranz, E., Buch, J., Gutierrez, A. y García-Sanz, R. (2022). Potential Survival Benefit for Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation after Nivolumab Therapy for Relapse/Refractory Hodgkin Lymphoma: Real-Life Experience in Spain. Biology of Blood and Marrow Transplantation, 26 (8), 1534-1542. https://doi.org/10.1016/j.bbmt.2020.02.003. | |
dc.identifier.issn | 1534-1542 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146695 | |
dc.description.abstract | Clinical trials have shown that nivolumab has remarkable activity against relapsed/refractory classical Hodgkin lymphoma (cHL). However, the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) as consolidation therapy in these patients remains controversial. We performed a retrospective analysis of data from 74 patients treated with nivolumab. The overall response rate was 58% (including 30.6% with complete responses). Treatment-related adverse events were reported in 56.8% of patients (grade ≥3 in 9.4%). The main reasons for nivolumab discontinuation were referral for transplantation (41.7% patients) and disease progression (37.5%). The 2-year overall survival (OS) rate was 52% for the entire series. Ultimately, 39 patients underwent allo-HSCT. The cumulative incidence of grade II-IV acute graft-versus-host disease was 33.3% (grade III-IV in 2 patients). The cumulative incidence of nonrelapse mortality was 13.2%. Among the patients who responded to nivolumab, the 2-year OS and progression-free survival (PFS) were higher in patients who underwent consolidation with allo-HSCT (77.5% versus 42.6% [P = .126] and 73.9% versus 27.2% [P = .025], respectively). Thus, the efficacy and safety of nivolumab were comparable to values reported in previous clinical trials. The percentage of patients who bridged to transplantation was high, indicating a preference for Spanish physicians. These results suggest that consolidation allo-HSCT increases OS and PFS. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier Science Inc | es |
dc.relation.ispartof | Biology of Blood and Marrow Transplantation, 26 (8), 1534-1542. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Hodgkin lymphoma | es |
dc.subject | Nivolumab | es |
dc.subject | Allogeneic transplantation | es |
dc.subject | Relapsed/refractory lymphoma | es |
dc.title | Potential Survival Benefit for Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation after Nivolumab Therapy for Relapse/Refractory Hodgkin Lymphoma: Real-Life Experience in Spain | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | http://doi.org/10.1016/j.bbmt.2020.02.003 | es |
dc.identifier.doi | 10.1016/j.bbmt.2020.02.003 | es |
dc.journaltitle | Biology of Blood and Marrow Transplantation | es |
dc.publication.volumen | 26 | es |
dc.publication.issue | 8 | es |
dc.publication.initialPage | 1534 | es |
dc.publication.endPage | 1542 | es |