dc.creator | Degenhardt, Frauke | es |
dc.creator | Ellinghaus, David | es |
dc.creator | Juzenas, Simonas | es |
dc.creator | Lerga Jaso, Jon | es |
dc.creator | Wendorff, Mareike | es |
dc.creator | Maya Miles, Douglas | es |
dc.creator | Calderón Sandubete, Enrique José | es |
dc.creator | Morilla Romero de la Osa, Rubén | es |
dc.creator | Franke, Andre | es |
dc.date.accessioned | 2023-05-23T13:47:41Z | |
dc.date.available | 2023-05-23T13:47:41Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Degenhardt, F., Ellinghaus, D., Juzenas, S., Lerga Jaso, J., Wendorff, M., Maya Miles, D.,...,Franke, A. (2022). Detailed stratified GWAS analysis for severe COVID-19 in four European populations. HUMAN MOLECULAR GENETICS, 31 (23), 3945-3966. https://doi.org/10.1093/hmg/ddac132. | |
dc.identifier.issn | 0964-6906 | es |
dc.identifier.issn | 1460-2083 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146550 | |
dc.description.abstract | Metabolic associated fatty liver disease (MAFLD) is the most prevalent form of liver disease
worldwide, accounting for a high liver-related mortality and morbidity with extensive multi organ involvement. This entity has displaced viral hepatitis as the main cause of severe
forms of hepatic diseases, although the onset and transition of MAFLD stages still remains
unclear. Nevertheless, innate and adaptive immune responses seem to play an essential
role in the establishment and further progression of this disease. The immune system is
responsible of safeguard and preserves organs and systems function, and might be
altered under different stimuli. Thus, the liver suffers from metabolic and immune changes
leading to different injuries and loss of function. It has been stablished that cell-cell
crosstalk is a key process in the hepatic homeostasis maintenance. There is mounting
evidence suggesting that MAFLD pathogenesis is determined by a complex interaction of
environmental, genetic and host factors that leads to a full plethora of outcomes.
Therefore, herein we will revisit and discuss the interplay between immune mechanisms
and MAFLD, highlighting the potential role of immunological markers in an attempt to
clarify its relationship. | es |
dc.description.sponsorship | Consejería de Salud , Junta de Andalucía | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad, Gobierno de España | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | OXFORD UNIV PRESS | es |
dc.relation.ispartof | HUMAN MOLECULAR GENETICS, 31 (23), 3945-3966. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | NAFLD | es |
dc.subject | NASH | es |
dc.subject | Immunology | es |
dc.subject | Fibrosis | es |
dc.subject | Biomarkers | es |
dc.title | Detailed stratified GWAS analysis for severe COVID-19 in four European populations | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Enfermería | es |
dc.relation.projectID | PE-0451- ́ 2018 | es |
dc.relation.projectID | PI16/01842, PI19/01404, PI19/00589 | es |
dc.relation.publisherversion | https://academic.oup.com/hmg/article/31/23/3945/6644888 | es |
dc.identifier.doi | 10.1093/hmg/ddac158 | es |
dc.journaltitle | HUMAN MOLECULAR GENETICS | es |
dc.publication.volumen | 31 | es |
dc.publication.issue | 23 | es |
dc.publication.initialPage | 3945 | es |
dc.publication.endPage | 3966 | es |
dc.contributor.funder | Consejería de Salud, Junta de Andalucía | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |