dc.creator | Abubakar, Usman | es |
dc.creator | Zulkarnain, Amni Izzati | es |
dc.creator | Rodríguez-Baño, Jesús | es |
dc.creator | Kamarudin, Norhidayah | es |
dc.creator | Elrggal, Mahmoud E. | es |
dc.creator | Elnaem, Mohamed Hassan | es |
dc.creator | Harun, Sabariah Noor | es |
dc.date.accessioned | 2023-05-18T14:21:39Z | |
dc.date.available | 2023-05-18T14:21:39Z | |
dc.date.issued | 2022-12-02 | |
dc.identifier.citation | Abubakar, U., Zulkarnain, A.I., Rodríguez-Baño, J., Kamarudin, N., Elrggal, M.E., Elnaem, M.H. y Harun, S.N. (2022). Treatments and Predictors of Mortality for Carbapenem-Resistant Gram-Negative Bacilli Infections in Malaysia A Retrospective Cohort Study. Tropical Medicine and Infectious Disease, 7 (12), 415. https://doi.org/10.3390/tropicalmed7120415. | |
dc.identifier.issn | 2414-6366 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146360 | |
dc.description.abstract | This study evaluated the treatments, mortality rate and patient-related factors associated with mortality. This is a retrospective study involving hospitalised patients with infections caused by carbapenem-resistant Gram-negative bacilli (CR-GNB) in a tertiary hospital in Malaysia from January 2018 to June 2020. A clinical pharmacist reviewed patients’ electronic records and collected the data according to a pre-designed form. Data were analysed using both descriptive and inferential tests. The study included 145 patients with CR-GNB infections including 77, 40 and 28 Acinetobacter baumannii, enterobacteriaceae and Pseudomonas aeruginosa, respectively. The mean age was 57.9 ± 15.8 years. Pneumonia (40.7%) and bacteremia (25.5%) were the most common infections. Meropenem (24.7%) and piperacillin-tazobactam (20.4%) were the most commonly used empiric antibiotics while colistin (63.3%) and amikacin (8.3%) were the most common definitive antibiotics. The mean duration before active antibiotics was 4.6 ± 3.3 days. Overall, the in-hospital mortality rate was 41.4%. Multivariate logistic regression analysis showed that intensive care unit (ICU) admission (adjusted odds ratio (AOR): 5.201; 95% confidence interval (CI): 1.603–16.872; p = 0.006), sepsis/septic shock (AOR: 3.430; 95% CI: 1.021–11.522; p = 0.049) and elevated serum creatinine (AOR: 2.752; 95% CI: 1.005–7.536; p = 0.049) were independently associated with mortality. The mortality rate among patients with CR-GNB infection is high. A high rate of inappropriate antibiotic use was observed, including combination antibiotic therapy and delays in starting active antibiotics. Mortality was significantly associated with ICU admission, sepsis/septic shock and elevated serum creatinine. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Tropical Medicine and Infectious Disease, 7 (12), 415. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | carbapenem-resistant gram negative bacilli | es |
dc.subject | carbapenem-resistant Acinetobacter baumannii | es |
dc.subject | carbapenem-resistant Enterobacteriaceae | es |
dc.subject | carbapenem-resistant Pseudomonas aeruginosa | es |
dc.subject | in-hospital mortality | es |
dc.subject | risk factors | es |
dc.title | Treatments and Predictors of Mortality for Carbapenem-Resistant Gram-Negative Bacilli Infections in Malaysia A Retrospective Cohort Study | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.projectID | 22UQU4320605DSR06 | es |
dc.relation.publisherversion | https://www.mdpi.com/2414-6366/7/12/415 | es |
dc.identifier.doi | 10.3390/tropicalmed7120415 | es |
dc.journaltitle | Tropical Medicine and Infectious Disease | es |
dc.publication.volumen | 7 | es |
dc.publication.issue | 12 | es |
dc.publication.initialPage | 415 | es |
dc.contributor.funder | Deanship of Scientific Research at Umm Al-Qura University | es |