dc.creator | Bodro, Marta | es |
dc.creator | Cervera, Carlos | es |
dc.creator | Linares, Laura | es |
dc.creator | Suárez, Belén | es |
dc.creator | Llopis, Jaume | es |
dc.creator | Sanclemente, Gemma | es |
dc.creator | Cordero Matia, María Elisa | es |
dc.creator | Moreno, Asunción | es |
dc.date.accessioned | 2023-05-17T13:57:03Z | |
dc.date.available | 2023-05-17T13:57:03Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Bodro, M., Cervera, C., Linares, L., Suárez, B., Llopis, J., Sanclemente, G.,...,Moreno, A. (2022). Polygenic Innate Immunity Score to Predict the Risk of Cytomegalovirus Infection in CMV D+/R- Transplant Recipients. A Prospective Multicenter Cohort Study. Frontiers in Immunology, 13, 897912. https://doi.org/10.3389/fimmu.2022.897912. | |
dc.identifier.issn | 1664-3224 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146253 | |
dc.description.abstract | Several genetic polymorphisms of the innate immune system have been described to
increase the risk of cytomegalovirus (CMV) infection in transplant patients. The aim of this
study was to assess the impact of a polygenic score to predict CMV infection and disease
in high risk CMV transplant recipients (heart, liver, kidney or pancreas). On hundred and
sixteen CMV-seronegative recipients of grafts from CMV-seropositive donors undergoing
heart, liver, and kidney or pancreas transplantation from 7 centres were prospectively
included for this purpose during a 2-year period. All recipients received 100-day
prophylaxis with valganciclovir. CMV infection occurred in 61 patients (53%) at 163
median days from transplant, 33 asymptomatic replication (28%) and 28 CMV disease
(24%). Eleven patients (9%) had recurrent CMV infection. Clinically and/or functionally
relevant single nucleotide polymorphisms (SNPs) from TLR2, TLR3, TLR4, TLR7, TLR9,
AIM2, MBL2, IL28, IFI16, MYD88, IRAK2 and IRAK4 were assessed by real time
polymerase chain reaction (RT-PCR) or sequence-based typing (PCR-SBT). A
polygenic score including the TLR4 (rs4986790/rs4986791), TLR9 (rs3775291), TLR3
(rs3775296), AIM2 (rs855873), TLR7 (rs179008), MBL (OO/OA/XAO), IFNL3/IL28B
(rs12979860) and IFI16 (rs6940) SNPs was built based on the risk of CMV infection
and disease. The CMV score predicted the risk of CMV disease with an AUC of the model
of 0.68, with sensitivity and specificity of 64.3 and 71.6%, respectively. Even though further studies are needed to validate this score, its use would represent an effective
model to develop more robust scores predicting the risk of CMV disease in donor/
recipient mismatch (D+/R-) transplant recipients. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | FRONTIERS MEDIA SA | es |
dc.relation.ispartof | Frontiers in Immunology, 13, 897912. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Cytomegalovirus | es |
dc.subject | Solid organ transplantation | es |
dc.subject | Infectious disease | es |
dc.subject | Multicenter study | es |
dc.subject | Innate immunity | es |
dc.title | Polygenic Innate Immunity Score to Predict the Risk of Cytomegalovirus Infection in CMV D+/R- Transplant Recipients. A Prospective Multicenter Cohort Study | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.projectID | FIS PI12/01743 | es |
dc.relation.projectID | PID2019 - 106658RB-I00 | es |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fimmu.2022.897912/full | es |
dc.identifier.doi | 10.3389/fimmu.2022.897912 | es |
dc.contributor.group | Universidad de Sevilla. CTS203 : Estudio de las enfermedades infecciosas | es |
dc.journaltitle | Frontiers in Immunology | es |
dc.publication.volumen | 13 | es |
dc.publication.initialPage | 897912 | es |
dc.contributor.funder | Ministerio de Sanidad y Consumo. España | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación. España | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |
dc.contributor.funder | Fondo Europeo de Desarrollo Regional (FEDER). Unión Europea. | es |