dc.creator | Ávila Román, Francisco Javier | es |
dc.creator | Gómez Villegas, Patricia | es |
dc.creator | Carvalho, Carla de | es |
dc.creator | Vigara, Javier | es |
dc.creator | Motilva Sánchez, Virginia | es |
dc.creator | León, Rosa | es |
dc.creator | Talero Barrientos, Elena Mª | es |
dc.date.accessioned | 2023-05-15T11:48:34Z | |
dc.date.available | 2023-05-15T11:48:34Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Ávila Román, F.J., Gómez Villegas, P., Carvalho, C.d., Vigara, J., Motilva Sánchez, V., León, R. y Talero Barrientos, E.M. (2023). Up-Regulation of the Nrf2/HO-1 Antioxidant Pathway in Macrophages by an Extract from a New Halophilic Archaea Isolated in Odiel Saltworks. Antioxidants, 12 (5), 1080. https://doi.org/10.3390/antiox12051080. | |
dc.identifier.issn | 2076-3921 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146020 | |
dc.description.abstract | : The production of reactive oxygen species (ROS) plays an important role in the progression of
many inflammatory diseases. The search for antioxidants with the ability for scavenging free radicals
from the body cells that reduce oxidative damage is essential to prevent and treat these pathologies.
Haloarchaea are extremely halophilic microorganisms that inhabit hypersaline environments, such as
saltworks or salt lakes, where they have to tolerate high salinity, and elevated ultraviolet (UV) and infrared
radiations. To cope with these extreme conditions, haloarchaea have developed singular mechanisms to
maintain an osmotic balance with the medium, and are endowed with unique compounds, not found
in other species, with bioactive properties that have not been fully explored. This study aims to assess
the potential of haloarchaea as a new source of natural antioxidant and anti-inflammatory agents. A
carotenoid-producing haloarchaea was isolated from Odiel Saltworks (OS) and identified on the basis of
its 16S rRNA coding gene sequence as a new strain belonging to the genus Haloarcula. The Haloarcula sp.
OS acetone extract (HAE) obtained from the biomass contained bacterioruberin and mainly C18 fatty
acids, and showed potent antioxidant capacity using ABTS assay. This study further demonstrates, for
the first time, that pretreatment with HAE of lipopolysaccharide (LPS)-stimulated macrophages results in
a reduction in ROS production, a decrease in the pro-inflammatory cytokines TNF-α and IL-6 levels, and
up-regulation of the factor Nrf2 and its target gene heme oxygenase-1 (HO-1), supporting the potential of
the HAE as a therapeutic agent in the treatment of oxidative stress-related inflammatory diseases. | es |
dc.description.sponsorship | Fondos europeos FEDER Programa Andalucía 2014–2020/US-1380844 y UHU-1257518 | es |
dc.description.sponsorship | Agencia Estatal de Investigación de España - PID2019-110438RBC22-AEI/FEDER | es |
dc.description.sponsorship | Junta de Andalucía - I+D+i-JA-PAIDI-Retos 2020-PY20 | es |
dc.description.sponsorship | VII Plan Propio de Investigación y Transferencia de la Universidad de Sevilla | es |
dc.description.sponsorship | Fundação para a Ciência e a Tecnologia de Portugal (FCT) - UIDB/04565/2020 y UIDP/04565/2020 | es |
dc.description.sponsorship | Associate Laboratory Institute for Health and Bioeconomy de Portugal (i4HB) - LA/P/0140/2020 | es |
dc.description.sponsorship | Beca “Margarita Salas” Universidad de Huelva. | es |
dc.format | application/pdf | es |
dc.format.extent | 15 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Antioxidants, 12 (5), 1080. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | bacterioruberin | es |
dc.subject | carotenoids | es |
dc.subject | fatty acids | es |
dc.subject | haloarchaea | es |
dc.subject | inflammation | es |
dc.subject | macrophages | es |
dc.subject | Odiel Saltworks | es |
dc.subject | oxidative stress | es |
dc.title | Up-Regulation of the Nrf2/HO-1 Antioxidant Pathway in Macrophages by an Extract from a New Halophilic Archaea Isolated in Odiel Saltworks | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.projectID | US-1380844 | es |
dc.relation.projectID | UHU-1257518 | es |
dc.relation.projectID | PID2019-110438RBC22-AEI/FEDER | es |
dc.relation.projectID | I+D+i-JA-PAIDI-Retos 2020-PY20 | es |
dc.relation.projectID | USE-VIPPI | es |
dc.relation.projectID | UIDB/04565/2020 | es |
dc.relation.projectID | UIDP/04565/2020 | es |
dc.relation.projectID | i4HB LA/P/0140/2020 | es |
dc.relation.publisherversion | https://doi.org/10.3390/antiox12051080 | es |
dc.identifier.doi | 10.3390/antiox12051080 | es |
dc.journaltitle | Antioxidants | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 1080 | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Agencia Estatal de Investigación. España | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | Universidad de Sevilla | es |
dc.contributor.funder | Fundação para a Ciência e a Tecnologia. Portugal | es |
dc.contributor.funder | Associate Laboratory Institute for Health and Bioeconomy (i4HB). Portugal | es |
dc.contributor.funder | Universidad de Huelva | es |