dc.creator | Calvo Gallego, José Luis | es |
dc.creator | Manchado Morales, Pablo | es |
dc.creator | Pivonka, Peter | es |
dc.creator | Martínez Reina, Francisco Javier | es |
dc.date.accessioned | 2023-05-04T14:28:24Z | |
dc.date.available | 2023-05-04T14:28:24Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Calvo Gallego, J.L., Manchado Morales, P., Pivonka, P. y Martínez Reina, F.J. (2023). Spatio-temporal simulations of bone remodelling using a bone cell population model based on cell availability. Frontiers in Bioengineering and Biotechnology, 11, 1060158. https://doi.org/10.3389/fbioe.2023.1060158. | |
dc.identifier.issn | 2296-4185 | es |
dc.identifier.uri | https://hdl.handle.net/11441/145421 | |
dc.description | This is an open-access article distributed
under the terms of the Creative
Commons Attribution License (CC BY). | es |
dc.description.abstract | Here we developed a spatio-temporal bone remodeling model to simulate the action of Basic Multicelluar Units (BMUs). This model is based on two major extensions of a temporal-only bone cell population model (BCPM). First, the differentiation into mature resorbing osteoclasts and mature forming osteoblasts from their respective precursor cells was modelled as an intermittent process based on precursor cells availability. Second, the interaction between neighbouring BMUs was considered based on a “metabolic cost” argument which warrants that no new BMU will be activated in the neighbourhood of an existing BMU. With the proposed model we have simulated the phases of the remodelling process obtaining average periods similar to those found in the literature: resorption ((Formula presented.) days)—reversal (∼8 days)—formation (∼65 days)—quiescence (560–600 days) and an average BMU activation frequency of ∼1.6 BMUs/year/mm3. We further show here that the resorption and formation phases of the BMU become coordinated only by the presence of TGF-β (transforming growth factor β), i.e., a major coupling factor stored in the bone matrix. TGF-β is released through resorption so upregulating osteoclast apoptosis and accumulation of osteoblast precursors, i.e., facilitating the transition from the resorption to the formation phase at a given remodelling site. Finally, we demonstrate that this model can explain targeted bone remodelling as the BMUs are steered towards damaged bone areas in order to commence bone matrix repair. | es |
dc.format | application/pdf | es |
dc.format.extent | 18 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers | es |
dc.relation.ispartof | Frontiers in Bioengineering and Biotechnology, 11, 1060158. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Basic multicellular units | es |
dc.subject | Resorption period | es |
dc.subject | Formation period | es |
dc.subject | BMU activation frequency | es |
dc.subject | Targeted bone remodelling | es |
dc.subject | TGF-β | es |
dc.subject | Reversal period | es |
dc.subject | BMU coupling | es |
dc.title | Spatio-temporal simulations of bone remodelling using a bone cell population model based on cell availability | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ingeniería Mecánica y de Fabricación | es |
dc.relation.projectID | PID2019-106969R | es |
dc.relation.projectID | 10.13039/501100011033 | es |
dc.relation.projectID | IC190100020 | es |
dc.relation.projectID | DP230101404 | es |
dc.relation.publisherversion | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1060158/full | es |
dc.identifier.doi | 10.3389/fbioe.2023.1060158 | es |
dc.contributor.group | Universidad de Sevilla. TEP111: Ingeniería Mecánica | es |
dc.journaltitle | Frontiers in Bioengineering and Biotechnology | es |
dc.publication.volumen | 11 | es |
dc.publication.initialPage | 1060158 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Agencia Estatal de Investigación. España | es |
dc.contributor.funder | Consejo Australiano de Investigación | es |